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Considering the clinical vignette from last week (elderly male with proximal muscle weakness). Staining the skeletal muscle biopsy with myoadenylate deaminase (MAD) can give the neuropathologist more information than just it’s presence or absence, as may be seen in adenosine monophosphate deaminase (AMPD) deficiency. Using the images, what other structures or ultrastructural clues can be yielded from myoadenylate deaminase (MAD) staining in this skeletal muscle biopsy? Frozen sections of skeletal muscle with Tubular Aggregate Myopathy (TAM) demonstrating a cluster of muscle fibers with ovoid eccentric to subsarcolemmal basophilic (blue) inclusions (1) with routine hematoxylin and eosin (H&E) stain, and...