arrow-right-realarrow-right-whitearrow-rightback-to-topdoctordownloadfacebookinstagramlogo-markerlogo-wordmarkpodcastsearchsearch_whitetwitter
Announcement
Due to inclement weather last week, we are still experiencing shipping delays.  Please call us with any questions. 
Close Announcement
Show/Hide Menu
Close Modal

Blog

Currently filtering by tag: FSGS tip lesion

FSGS Tip Lesion – Secondary

Article
The patient is a 64-year-old male with a history of diabetes mellitus, hypertension, and hyperlipidemia, who presents with an increased creatinine of 1.8 mg/dl and proteinuria (UPCR 2.5 g/g). Serologic workup is completely negative. A renal biopsy was performed and shows nodular glomerulosclerosis (Fig 1) and arteriolar hyalinosis characteristic of diabetic glomerulopathy. Additionally, the glomeruli focally show areas of segmental glomerulosclerosis associated with endocapillary foam cells. These lesions are located at the take-off point of the proximal tubule (Fig 1) and reminiscent of the glomerular lesions seen in the tip variant of FSGS. Electron microscopy shows mesangial matrix expansion, mostly...
Read More

FSGS Tip Lesion

Article
This biopsy is from a 35-year-old male with no significant medical history, who presents with sudden onset nephrotic syndrome. At presentation, the UPCR was 8.2 g/g and the serum albumin was 1.1 g/dl. Renal function was preserved (SCr 1.1 mg/dl). The biopsy shows frequent areas of segmental glomerulosclerosis (FSGS), associated with endocapillary foam cells and epithelial cell capping, predominantly involving the takeoff point of the proximal tubule (fig 1). Focally, the areas of segmental sclerosis herniate into the proximal tubule. Immunofluorescence is completely negative within the glomeruli, and electron microscopy (fig 2) shows diffuse epithelial foot process effacement. The findings...
Read More
 

Arkana
Announcement

Posted February 23rd 2021
Due to inclement weather last week, we are still experiencing shipping delays.  Please call us with any questions.