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Armanni Ebstein Lesion

Armanni-Ebstein lesion, originally described by Luciano Armanni in 1872, is characterized by vacuolization and PAS-positive glycogen accumulation within the cytoplasm of tubular epithelial cells (Fig 1). The cytoplasm of these cells stains pale on PAS following diastase digestion (Fig 2). These changes predominantly involve the terminal straight portion of the proximal convoluted tubule and are usually seen in the outer renal medulla. Armanni-Ebstein lesions have been mostly described in poorly controlled diabetics and patients with diabetic ketoacidosis; however, similar lesions have been reported in patients with Fanconi Syndrome and alcoholic ketoacidosis.  Of note, while not the original description, the term...