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Currently filtering by tag: Malignancy

Twitter Poll (February 6, 2019)

Minimal change disease, twitter poll, arkana laboratories, renal pathology, kindey biopsy
Answer: B Minimal change disease is the most common glomerular disease associated with thymoma. Classically, the solid tumors most commonly associated with MN are lung, bronchus, and gastric cancers, followed by renal cell, prostate and thymoma. Other cancers reported with MN are colorectal, pancreatic, esophageal and hepatic carcinomas. References: Ronco PM. Paraneoplastic glomerulopathies: New insights into an old entity. Kidney Int 56: 355–377, 1999 Bacchetta J, Juillard L, et al. Paraneoplastic glomerular diseases and malignancies. Crit Rev Oncol Hematol 70: 39–58, 2009 Lefaucheur C, Stengel B, et al. Membranous nephropathy and cancer: Epidemiologic evidence and determinants of high-risk cancer association....

THSD7A

Granular capillary loop staining for thrombospondin type-1 domain-containing 7A (THSD7A). Our understanding of the pathogenesis of membranous glomerulopathy was transformed with the discovery that most cases of ‘idiopathic’ MN are due to autoantibodies directed against the phospholipase A2 receptor (PLA2R) protein.(1) More recently, thrombospondin type-1 domain-containing 7A (THSD7A) protein was described as a second antigenic target of autoantibodies in this disease.(2) Recent reports have implicated malignancy as the underlying etiology in some cases of THSD7A-associated MN.(3-5) 1. Beck LH, Bonegio RG, Lambeau G, et al. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med...