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Currently filtering by tag: Membranous glomerulopathy

Twitter Poll (September 9, 2021)

NELL1
  Which of the following membranous antigens has been recently identified and associated with underlying malignancy? A) NELL1 B) PLA2R C) EXT1/2 D) THSD7A   Answer: A) NELL1 NELL1, or neural epidermal growth factor-like 1 protein is a recently identified target antigen that has been associated with underlying malignancy in a subset of patients with membranous glomerulopathy. For further information, see references below. References: Caza T, Hassen S, Dvanajscak Z, Kuperman M, et al. NELL1 is a target antigen in malignancy-associated membranous nephropathy. Kidney Int 2020 Aug 20:S0085-2538(20)30956-X. Sethi S, Debiec H, Madden B, Charlesworth MC, et al. Neural epidermal...

Diagnose This (August 17, 2020)

Membranous Glomerulopathy, PLA2R, Diagnose This, renal pathology, Arkana Laboratories
What is your diagnosis for this patient with nephrotic syndrome?     ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​   ​ ​     ​...

Resolving Membranous Nephropathy

Arkana Laboratories, renal pathology, Membranous Nephropathy
A 40-year-old white male presents with 3 grams/24 hr of proteinuria and swelling around his ankles. He reports that he has had foamy urine over the last 4 months, but was unable to go to a doctor till now because of lack of insurance. Image 1 and image 2 shows irregularly thickened glomerular basement membranes with lamellation. Image 3 shows numerous "holes" on silver stain. Images 4, 5, and 6 show weak staining for IgG, kappa, and lambda, respectively. Membranous nephropathy in a resolving phase can be a tricky diagnosis since the immunofluorescence staining may be extremely weak or negative....

Membranous Lupus Nephritis

Membranous Lupus Nephritis, arkana laboratories, renal pathology, kidney biopsy
The patient is a 19-year-old female who presents with hematuria, nephrotic range proteinuria, and a creatinine of 1.2 mg/dL. She has a recent diagnosis of systemic lupus erythematosus. Figure 1 shows a normal glomerulus without "spikes" and "holes" of the glomerular basement membranes. Figure 2 shows no significant interstitial fibrosis. Figures 3, 4, 5, & 6 shows IgG, kappa, lambda, and C1q respectively. Image 7 and 8 shows subepithelial deposits. This is a case of membranous lupus nephritis (ISN/RPS Class V). By definition, no proliferative changes (crescents, fibrinoid necrosis, endocapillary hypercellularity) are seen within the glomeruli in a pure class...

Membranous Nephropathy After Transplantation

Membranous Nephropathy, renal diseases, kidney biopsy, arkana laboratories
The biopsy shows a recurrent membranous nephropathy within a transplant. Figure 1 shows "spikes" and "holes." Figure 2 shows mild interstitial fibrosis. Figures 3, 4, 5, and 6 shows IgG, kappa, lambda, and PLA2r, respectively. Figure 7 shows subepithelial and intramembranous deposits. Membranous nephropathy can arise in the graft from recurrence of the original disease, a de novo disease, and rarely as a donor-derived disease. Recurrence of the original disease can be seen as early as one week post transplant. Most cases of recurrent membranous nephropathy occur within the first few months following transplantation, whereas de novo membranous nephropathy usually...

Disease Week: Membranous Glomerulopathy

Monday History of MG Timeline of major discoveries in membranous glomerulopathy. Heymann nephritis was unique as a model of membranous glomerulopathy when it was reported in 1959 because it was the first to produce renal disease through autosensitization. http://pediatrics.aappublications.org/content/7/5/691 The antigenic target of Heymann nephritis (megalin) is largely absent from human podocytes but does have a role in human autoimmune disease as the antigenic target of anti-brush border antibody disease (LRP2-assoc nephropathy). https://jasn.asnjournals.org/content/29/2/644.long The case report of placental transfer of maternal antibodies directed against the neutral endopeptidase protein in fetal glomeruli was the first description of a podocyte antigen as...

Twitter Poll (February 6, 2019)

Minimal change disease, twitter poll, arkana laboratories, renal pathology, kindey biopsy
Answer: B Minimal change disease is the most common glomerular disease associated with thymoma. Classically, the solid tumors most commonly associated with MN are lung, bronchus, and gastric cancers, followed by renal cell, prostate and thymoma. Other cancers reported with MN are colorectal, pancreatic, esophageal and hepatic carcinomas. References: Ronco PM. Paraneoplastic glomerulopathies: New insights into an old entity. Kidney Int 56: 355–377, 1999 Bacchetta J, Juillard L, et al. Paraneoplastic glomerular diseases and malignancies. Crit Rev Oncol Hematol 70: 39–58, 2009 Lefaucheur C, Stengel B, et al. Membranous nephropathy and cancer: Epidemiologic evidence and determinants of high-risk cancer association....

Art of Medicine: Membranous Glomerulopathy

Membranous Glomerulopathy, Art of Medicine
The painting above depicts membranous glomerulopathy.   A single glomerular capillary loop with confluent subepithelial and intramembranous electron dense deposits along the glomerular basement membrane is shown.  Podocytes are showing foot process effacement and microvillous transformation, which results in loss of the filtration barrier leading to nephrotic syndrome.  An electron micrograph from a patient with membranous glomerulopathy is shown below. Membranous glomerulopathy is the second most common cause of nephrotic syndrome in adults.  A majority of cases are considered primary with autoantibodies directed against the podocyte antigens phospholipase A2 receptor (PLA2R, ~70% of cases) or thrombospondin type 1 domain containing 7A...