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Currently filtering by tag: Oxalate nephropathy

Oxalate Nephropathy

This biopsy is from a patient with metabolic acidosis, a CPK of 8000 mg/dl a creatinine of 22 mg/dl on admission. The H&E stained section shows birefrigent bluish crystals consistent with calcium oxalate crystals on a background of acute tubular injury. The extensive number of intratubular crystals associated with acute tubular injury support renal oxalosis as the cause of the renal failure. (H&E with polarized light, 200x)

Oxalate Nephropathy

H&E stained section (Fig. 1) demonstrating acute tubular injury with frequent translucent intratubular crystalline deposits on a background of severe tubulointerstitial scarring. The crystals show birefringence under polarized light (Fig. 2) characteristic of renal oxalosis. After the biopsy, this 60-year-old male admitted consumption of small quantities of ethylene glycol over the past 16 months.  Other causes of secondary renal oxalosis include enteric forms (Crohn’s disease, celiac sprue, pancreatic insufficiency, small intestinal or gastric bypass or resection), over-ingestion of oxalate containing foods (e.g., dark leafy vegetables, rhubarb, kale, starfruit, tea, spinach, sesame seeds, almonds, peanuts, beets, buckwheat flour, chocolate soy milk),...