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Currently filtering by tag: oxidative staining

Tubular Aggregates

Tubular aggregates in H&E stain of muscle/nerve biopsy
Considering the clinical vignette from the prior week (elderly male with proximal muscle weakness). Staining the skeletal muscle biopsy with Hematoxylin and Eosin (H&E) in combination with frozen sections evaluated with Modified Gomori Trichrome (MGT) and oxidative stains can provide the neuropathologist with much information, including clues as to the ultrastructural abnormality of this myopathy. Electron microscopy was pursued. Using the images, what is the ultrastructural abnormality shown below in this skeletal muscle biopsy?   Formalin-fixed paraffin-embedding (FFPE) tissue section of skeletal muscle with Tubular Aggregate Myopathy (TAM) demonstrating four nearby muscle fibers with round to ovoid eccentric and subsarcolemmal...

Modified Gomori Trichrome (MGT)

Modified Gomori Trichrome (MGT)
Considering the clinical vignette from the prior week (elderly male with proximal muscle weakness). Staining the skeletal muscle biopsy in combination with Modified Gomori Trichrome (MGT) and oxidative stains can provide the neuropathologist with much information, including clues as to the ultrastructural abnormality of this myopathy. Using the images below, True or False:  The Modified Gomori Trichrome (MGT) staining in this skeletal muscle biopsy is definitive for mitochondria.   Frozen sections of skeletal muscle with Tubular Aggregate Myopathy (TAM) demonstrating two near by muscle fibers with round to ovoid eccentric and subsarcolemmal inclusion-type material with dense bright fuchsinophilic (red) staining...