arrow-right-realarrow-right-whitearrow-rightback-to-topdoctordownloadfacebookinstagramlogo-markerlogo-wordmarkpodcastsearchsearch_whitetwitter
Close Modal

Blog


Currently filtering by tag: Peritubular capillaritis

Twitter Poll (February 20, 2019)

Antibody-Mediated Rejection, Twitter Poll, Arkana Laboratories
ANSWER: B The findings are suspicious for active antibody-mediated rejection (ABMR), based on the presence of moderate glomerulitis (g2), severe peritubular capillaritis (ptc3) and C4d staining in PTCs (C4d2). Serologic evidence of DSA is advised in order to meet the criteria for diagnosis. Reference: Haas M, et al. The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T-cell mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials. Am J Transplant. 2018; 1-15.

Antibody-Mediated Rejection

This biopsy was performed on a 37-year-old female with a history of type 1 diabetes mellitus, status post second deceased donor renal transplant, who now presents with allograft dysfunction (Cr 3.1 mg/dl) and mild proteinuria (UPC 1.1 g/g). No donor-specific antibody (DSA) data was available at the time of the biopsy. The biopsy shows severe glomerulitis and chronic transplant glomerulopathy (Fig 1), along with mild peritubular capillaritis (Fig 2) and diffusely positive C4d staining in peritubular capillaries (Fig 3). Based on the Banff 2017 kidney meeting report, this case can now be diagnosed as chronic active antibody-mediated rejection, and the...