arrow-right-realarrow-right-whitearrow-rightback-to-topdoctordownloadfacebookinstagramlogo-markerlogo-wordmarkpodcastsearchsearch_whitetwitter
Close Modal

Blog


Currently filtering by tag: Podocytopathy

Diagnose This (April 22, 2019)

diffuse foot process effacement, Minimal change disease, Nephrotic syndrome, Podocytopathy, Arkana Laboratories
What is this finding and what diagnoses does it imply?       ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​   ​ ​    ...

Twitter Poll (January 23, 2019)

CLL/SLL Patients, arkana laboratories,
ANSWER: A Although glomerular disease in patients with CLL/SLL is less common, the most frequent patterns of glomerular injury seen include MPGN (immune complex mediated), MCD, membranous GN, and monoclonal immunoglobulin deposition disease. The most common form of kidney involvement in patients with CLL/SLL is the presence of direct infiltration of the kidney parenchyma by leukemic cells. Although glomerular disease in patients with CLL/SLL is less common, they can be present.  The glomerular pattern of injury frequently seen in these group of patients include membranoproliferative glomerulonephritis (immune complex mediated), minimal change disease, membranous nephropathy, and monoclonal immunoglobulin deposition disease (nonamyloid...

Minimal Change Disease

Minimal Change Disease, teaching point, arkana laboratories, renal pathology
A 70-year-old female presents with nephrotic range proteinuria. She had been in her regular state of health until 2 weeks ago when she noticed swelling in her ankles and that her shoes no longer fit. She went to her family practitioner who sent her to a cardiologist to rule out congestive heart failure. Her troponin levels were normal and her creatinine on routine examination was 7.5 mg/dL. She was admitted to the hospital and an emergent kidney biopsy was requested. Figure 1 shows a normal glomerulus. Figure 2 shows no significant interstitial fibrosis. Figure 3 shows severe arteriosclerosis. Figure 4...

Diagnose This (October 29, 2018)

Minimal Change Disease
What class of disease does this patient have and how did they present clinically?           ​   ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​...

Focal Segmental Glomerulosclerosis (FSGS), Tip Variant

This biopsy was performed on a 9-year-old female with no significant past medical history, who presents with nephrotic syndrome. The serum creatinine at the time of the biopsy was 0.7 mg/dl. The UPCR was 9.6 g/g. Serum albumin was 2.1 g/dl. Complement levels and ANA were normal/negative. The biopsy shows glomeruli with minimal mesangial matrix expansion and hypercellularity (Fig 1), in the absence of segmental glomerulosclerosis or proliferative lesions. Immunofluorescence was negative for IgA, IgG, IgM, C3, C1q and kappa and lambda light chains (not shown). Electron microscopy shows widespread blunting, widening and effacement of epithelial foot processes (Fig 2),...