arrow-right-realarrow-right-whitearrow-rightback-to-topdoctordownloadfacebookinstagramlogo-markerlogo-wordmarkpodcastsearchsearch_whitetwitter
Close Modal

Blog


Currently filtering by tag: Renin

Chronic Cyclosporine Toxicity in Pediatric Nephrotic Syndrome

Pediatric Nephrotic Syndrome, childhood nephrotic syndrome, CSA, CNI, juxtaglomerular apparatus
This biopsy is from a 9-year-old boy who developed pediatric nephrotic syndrome in the first year of life and has been maintained on cyclosporine (CSA) due to frequent relapses. He had not had a biopsy before and was clinically on remission, considering switching to rituximab. The biopsy was performed to assess chronic changes and the presence of histologic signs of chronic calcineurin inhibitor (CNI) toxicity CNI toxicity. His serum creatinine was 0.6 mg/dL. He was also on lisinopril for proteinuria control. He was not hypertensive. The biopsy contained a total of 61 glomeruli, four of which were globally sclerotic. No...

Twitter Poll (November 30, 2018)

ANSWER: D The cells of Goormaghtigh, AKA extraglomerular mesangial cells, lacis cells or Polkissen cells, are part of the juxtraglomerular apparatus. Ultrastructurally, these cells resemble mesangial cells. The lacis cells function as a physiologic liaison between the macula densa and arteriolar smooth muscle cells and the arteriolar granular myoepithelioid cells. They play an important role in renal autoregulation of blood flow to the kidney and regulation of systemic blood pressure through the renin-angiotensin system. References: Eknoyan G, Rubens R, Lameire R. The juxtaglomerular apparatus of Norbert Goormaghtigh – a critical appraisal. Nephrol Dial Transplant 2009; 24:3876-81. Christensen JA, Bohle A...