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KDIGO Connections: Membranous Glomerulopathy

Welcome to the first post in our new series KDIGO Connections, a series in which we are asking our nephrologist colleagues to educate us in real-world experiences treating kidney disease. In this series, Dr. David Bourne will be kicking it off with KDIGO guidelines for a kidney disease in visual abstract form. Our hope is that these posts will foster discussion regarding these diseases and how different providers approach them. Please share any points, pearls, questions, caveats, thoughts, or experience you have on the presented disease letting us all learn from your experience!  

THSD7A

Granular capillary loop staining for thrombospondin type-1 domain-containing 7A (THSD7A). Our understanding of the pathogenesis of membranous glomerulopathy was transformed with the discovery that most cases of ‘idiopathic’ MN are due to autoantibodies directed against the phospholipase A2 receptor (PLA2R) protein.1 More recently, thrombospondin type-1 domain-containing 7A (THSD7A) protein was described as a second antigenic target of autoantibodies in this disease.2 Recent reports have implicated malignancy as the underlying etiology in some cases of THSD7A-associated MN.3-5 1. Beck LH, Bonegio RG, Lambeau G, et al. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med...