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Archive: November 2020

Twitter Poll (November 25, 2020)

Article
twitter poll, calcium oxalate, renal pathology, arkana laboratories
Answer: B Ethylene glycol toxicity due to oral ingestion classically shows acute tubular injury characterized by epithelial simplification, loss of brush border, vacuolization, and reactive nuclear changes in association with intratubular calcium oxalate deposition. Of note, these crystals are polarizable whereas calcium phosphate crystals are not.  
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Nerve Twigs Within Endomysial Connective Tissue

Article
nerve twigs, Neuro notes, molecular pathology, neuropathology, renal pathology, arkana laboratories
This week's Neuro Notes shows ultrastructural examination of a muscle biopsy can sometimes yield additional useful information, such as evaluation of these small nerve twigs within the endomysial connective tissue. Electron photomicrograph, 6000x original magnification.
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Arkana Holiday Tales: Dr. Larsen

Article
Larsen, Thanksgiving, renal pathology, Arkana Holiday Tales, kidney path
Happy Thanksgiving!   While we might not all be able to gather this year, Dr. Larsen gives us something to look forward to next year and reminds us of why Thanksgiving is his favorite holiday!      
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Diagnose This (November 23, 2020)

Article
C3-dominant immune-complex, neutrophilic endocapillary hypercellularity, diagnose this, renal pathology, kidney biopsy, arkana laboratories
Based on the image provided, what would be your leading diagnosis with C3-dominant immune-complex deposition?       ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​...
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Arkana Holiday Tales: Dr. Boils

Article
Today’s Arkana Holiday Tales episode features Dr. Boils and all things related to birthdays! Listen as she explains why birthdays are her favorite holiday and how to make a cake.   P.S.- Happy birthday Dr. Boils and Dr. Ambruzs!🎂🎈      
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Macrophagic Myofasciitis (MMF)

Article
Macrophagic Myofasciitis (MMF), neuro notes, arkana laboratories, neuropathology
This previously healthy pediatric patient presented with peculiar facial muscle hypertrophy, and genetic testing revealed one pathologic variant and two variants of uncertain significance (VUSs).  A muscle biopsy of the thigh was performed to further evaluate this patient.  Frozen sections and ultrastructural examination images of the inflammatory infiltrate are shown below.  What is your diagnosis?     ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​...
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Diagnose This (November 16, 2020)

Article
glomerulomegaly, arkana laboratories, renal pathology, diagnose this, kidney pathology
  What conditions would be in your differential diagnosis for this finding? (Hint: large glomerulus)       ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​...
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Twitter Poll (November 11, 2020)

Article
NCAM-1, NCAM-1 associated membranous nephropathy, PLA2R, Twitter Poll, Arkana Laboratories
Answer: B In a recent article by Caza et al, NCAM-1 associated membranous nephropathy has been shown to be associated with systemic lupus erythematosus. Clinically, the article showed that the cases had a female predominance and were seen in younger patients than that typically seen in PLA2R or THSD7A-associated membranous nephropathy. In their cohort, NCAM-1-associated membranous made up approximately 7% of all membranous lupus nephritis cases (see reference).   Reference: Caza T, Hassen S, Kuperman M, et al (in press). Neural cell adhesion molecule 1 is a novel autoantigen in membranous lupus nephritis. Kid Int (2020) DOI: https://doi.org/10.1016/j.kint.2020.09.016.  
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Arkana
Announcement

Posted December 28th 2020
We are now offering IHC and ISH testing for evaluation of the presence of SARS-CoV-2 (aka COVID-19 and novel 2019 coronavirus).
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