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Archive: January 2021

Arkana Live – February 2021

february, Renal Intratubular Casts, january, december, Endocarditis-Related Glomerulonephritis, Infection-Related Glomerulonephritis, Light Microscopy, august, FSGS, september, october, July, Arkana Live, arkana laboratories
Did you enjoy the last Arkana Live? Don't miss part 2! Join us on February 13th as Dr. Zeljko Dvanajscak will be continuing his session on casts.   Register here: Arkana Live February 2021  

Denervation MCQ

Denervation MCQ, Denervation type changes, neuropathology, neuro notes, arkana laboratories
Frozen section of skeletal muscle stained with nonspecific esterase. (Original magnification:  100x) A 45-year old male firefighter with diabetes mellitus presents with chief complaint of lower back pain, right proximal thigh weakness, and minimally elevated CPK. Spine imaging shows multi-level degenerative joint disease and moderate spondylolisthesis.  A skeletal muscle biopsy is obtained from the patient’s right thigh.  What findings are seen in the esterase stained frozen section shown of the right rectus femoris?   Answer: The findings are those of mild active/ongoing denervation-type change. The muscle fibers of interest are variably atrophic and acutely angulated with a suggestion of a...

Episode 1: Representativeness

Stick to Your Knowledge, Never Be Afraid To Ask Questions, Making Time, How to Build A Reputation, Doing the Best You Can, Know Who Is In the Audience, Expanding the Differential Diagnosis, Knowing What Is Normal, Answer the Question, Knowing What You Know, Looking At Every Component, gestalt diagnosis, going deep, examining all the material, Lumping or Splitting, Focus, Using Therapy to Guide a Diagnosis, knowing the therapy, Severity of Change, principles of pathology, representativeness, arkana labs, renal path
🚨New Series Alert! 🚨   Dr. Silva offers his advice as a leader in kidney pathology along with pearls that all pathologists, nephrologists, and physicians should know in his new series, Principles of Pathology. Tune in each week for a new episode!  

Diagnose This (January 25, 2021)

Asteroid Body, Sarcoidosis, renal pathology, arkana laboratories, pathology of the kidney
What is the name of the finding at the end of the arrow and what condition is it classically associated with?       ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​...

Satellite Cells

Satellite Cells, Neuro Notes, neuropathology, arkana laboratories
An adult patient with proximal muscle weakness presents with CK 4400 and skeletal muscle biopsy of the thigh shows frequent regenerating and necrotic muscle fibers. In this electron micrograph of skeletal muscle, what are the structures indicated by the black arrows? Satellite cells are a normal population of undifferentiated cells within a skeletal muscle fiber that is capable of differentiating into myoblasts (i.e. stem cell-like properties), hence providing a source to produce new myotubes, as well as regeneration after injury (i.e. necrotizing myopathy).  The figure demonstrates satellite cells between the basal lamina and plasma membrane.  One of the satellite cells...

Twitter Poll (January 20, 2021)

Immunotactoid Glomerulopathy, Immunotactoid, renal pathology, arkana laboratories
Answer: A, Immunotactoid Immunotactoid Glomerulopathy is characterized by parallel microtubular deposits with lucent cores which are classically greater than 30 nm by electron microscopy. Both fibrillary and amyloid fibrils are typically characterized as non-branching randomly oriented fibrils which range usually between 10-20 nm and 7-12 nm, respectively. Light chain deposition disease classically shows characteristic punctate, powdery deposits within glomeruli and tubular basement membranes by electron microscopy.  

Diagnose This (January 19, 2021)

Infection-Associated Glomerulonephritis, diagnose this, arkana laboratories, renal disease of the kidney
Based on the electron microscopic image, what would be your initial underlying clinical concern for the findings seen?       ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​...