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Development of acute kidney injury (AKI) in the setting of COVID-19 substantially worsens outcomes, with increased morbidity and mortality, and has been a recent area of investigation. The painting shown above includes two common disease manifestations in the setting of Coronavirus Disease-2019 (COVID19), which include collapsing glomerulopathy and myoglobin cast nephropathy. Histologic images of each of these entities are shown below. Collapsing glomerulopathy, also known as COVID-19-associated nephropathy (COVAN), is one of the most common causes of acute kidney injury (as well as nephrotic syndrome) in patients with COVID-19. COVAN results from SARS-CoV-2 acting as a 'second hit' to individuals...