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Archive: Diagnose This!

Diagnose This (July 6,2020)

light chain deposition disease, Diagnose This, Arkana Laboratories, renal pathology
What is your diagnosis based on the EM image provided?     ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​   ​ ​     ​...

Diagnose This (May 18 ,2020)

Diagnose This!, anti-Coagulation
The light microscopic image demonstrates acute tubular injury with numerous occlusive red blood cell casts, which, despite obtaining deeper levels, is out of proportion to the degree of glomerular injury. While a few glomeruli showed occasional red blood cells within Bowman's space, there was no evidence of overt glomerular injury or activity such as cellular crescent formation, fibrinoid necrosis, or endocapillary hypercellularity. Thus, while it is a non-specific finding, this degree of red blood cell casts without glomerular proliferation should raise the pathologist's suspicion for anti-coagulation induced nephropathy. It is essential for the pathologists to probe further into not only...

Diagnose This (April 27 ,2020)

myoglobin cast, diagnose this
The microscopic image shows an H/E stain at high power of tubules displaying proximal tubular injury with epithelial thinning, reactive nuclear change, and intratubular, eosinophilic pigmented casts with a globular to beaded/ropey appearance. When casts with this morphology are found, the next step is to identify if the nature of the cast, including myoglobin and hemoglobin. In this case, the casts stained strongly for myoglobin, which fit clinically as the patient was suffering from rhabdomyolysis secondary to statin use. Aside from drugs, the clinical differential diagnosis for rhabdomyolysis includes physical trauma (i.e. intense exercise, seizure), toxins (i.e. snake venom), inflammatory...

Diagnose This (April 20 ,2020)

TMAF pathology report, Diagnose This!, Arkana Laboratories
What is your diagnosis and possible differential for the finding?     ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​   ​ ​     ​...

Diagnose This (March 30,2020)

armanni-ebstein, diagnose this, arkana laboratories
What is the name of this rare finding typically seen in the outer medulla? ​   ​ ​   ​ ​   ​   ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​...

Diagnose This (March 16,2020)

What is your diagnosis?     ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​   ​ ​     ​   ​   ​ ​  ...

Diagnose This (February 24, 2020)

renal oxalosis, Diagnose This
The light microscopic image demonstrates multiple large, polarizable intratubular crystals characteristic of calcium oxalate. While an occasional calcium oxalate crystal is not uncommon to see in renal biopsies, especially in patients with chronic kidney disease, this case demonstrated numerous crystals throughout the sample consistent with a diagnosis of renal oxalosis. Renal oxalosis is typically a progressive tubulointerstitial disease (although it can occur acutely) with many causes which can be classified as secondary to increased ingestion, increased absorption, decreased excretion, or vitamin deficiency. Increased enteric absorption of oxalate occurs secondary to malabsorptive states such as gastric/intestinal bypass surgery (as seen in...

Diagnose This (February 17, 2020)

Renal atheroembolic disease, diagnose this!, Arkana Laboratories
Question: What is the Diagnosis?   ​   ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​     ​   ​ ​   ​   ​ ​   ​   ​  ...

Diagnose This! (February 3, 2020)

Anti-Brush Border Antibody Disease (ABBA), Arkana laboratories, Diagnose This!
What is your diagnosis?    ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​   ​ ​     ​   ​   ​ ​   ​...

Diagnose This (December 2, 2019)

Glomerular Basement Membrane, Diagnose This, Arkana Laboratories
What is your diagnosis?     ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​   ​ ​     ​   ​   ​ ​  ...