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Daignose This (June 27, 2022)

Clarissa Cassol, MD renal pathologist at arkana laboratories
By Clarissa Cassol, MD

Jun 28, 2022

Endocapillary Hypercellularity B

In a patient who is an IV drug user and IF showing C3 only staining, what is your diagnosis?

infection-related glomerulonephritis

The image shows global endocapillary hypercellularity with numerous neutrophils (exudative glomerulonephritis). The patient was found to have tricuspid valve endocarditis. Given the presence of C3-only deposits, paraffin immunofluorescence was performed to rule out “masked” deposits and was negative. The findings are consistent with infection-related glomerulonephritis.


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