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Diagnose This (January 31, 2022)

Clarissa Cassol, MD renal pathologist at arkana laboratories
By Clarissa Cassol, MD

Feb 01, 2022

anti-brush border antibody disease

This is the IgG immunofluorescence from the biopsy of a 75-year-old female with AKI requiring dialysis. What is your diagnosis?

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The picture shows tubular brush border and granular tubular basement membrane staining for IgG. There is also segmental granular glomerular basement membrane staining. This combination of findings is consistent with anti-brush border antibody disease (ABBA), which can be further confirmed by staining with anti-LRP2 (a.k.a. megalin). Normally, LRP2 highlights tubular brush borders only; in ABBA, it is also present in the tubular basement membrane deposits (picture 2).

anti-brush border antibody disease

References

https://doi.org/10.1681/ASN.2017060664

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Quick note: This post is to be used for informational purposes only and does not constitute medical or health advice. Each person should consult their own doctor with respect to matters referenced. Arkana Laboratories assumes no liability for actions taken in reliance upon the information contained herein.