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Research Publications

Arkana is a learning, teaching, innovating practice with one unifying passion – to actively work toward the day that our research yields breakthroughs that make our services unnecessary. Read about some of our latest publications below.


Recent Publications

Abid, Q., Best Rocha, A., Larsen, C., Schulert, G., Marsh, R., Yasin, S., C., P.-R., Valentini, R., Adams, M., and Baracco, R. (2020). APOL1-Associated Collapsing Focal Segmental Glomerulosclerosis in a Patient With Stimulator of Interferon Genes (STING)-Associated Vasculopathy With Onset in Infancy (SAVI). Am J Kid Dis 75, 287-290.

Cossey, N., L., Dvanajscak, Z., and Larsen, C.P. (2020). A diagnostician’s field guide to crystalline nephropathies. Semin Diagn Pathol 37, 135-142.

Dvanajscak, Z., Cossey, L.N., and Larsen, C.P. (2020). A practical approach to the pathology of renal intratubular casts. Semin Diagn Pathol 37, 127-134.

Larsen, C., Bourne, T., Wilson, J., Saqqa, O., and MA., S. (2020). Collapsing Glomerulopathy in a Patient With Coronavirus Disease 2019 (COVID-19). Kidney International Reports.

Larsen, C.P., Sharma, S.G., Caza, T.N., Kenan, D.J., Storey, A.J., Edmondson, R.D., Herzog, C., and Arthur, J.M. (2020). Serum amyloid P deposition is a sensitive and specific feature of membranous-like glomerulopathy with masked IgG kappa deposits. Kid Int 97, 602-608.

Nasr, S.H., Larsen, C.P., Sirac, C., Theis, J.D., Domenger, C., Chauvet, S., Javaugue, V., Hogan, J.J., Said, S.M., Dasari, S., et al. (2020). Light chain only variant of proliferative glomerulonephritis with monoclonal immunoglobulin deposits is associated with a high detection rate of the pathogenic plasma cell clone. Kidney Int 97, 589-601.

Best Rocha, A., Larsen, C.P., Delyria, P.A., Polavaram, L.S., Said, S.M., Shibata, R.S., Rech, K.L., and Nasr, S.H. (2019). α1-Heavy Chain Deposition Disease With Negative Immunofluorescence Staining on Renal Biopsy. Kidney Int Rep 4, 178-183.

Cassol, C.A., Williams, M.P.A., Caza, T.N., and Rodriguez, S. (2019). Renal and pulmonary thrombotic microangiopathy triggered by proteasome-inhibitor therapy in patient with smoldering myeloma: A renal biopsy and autopsy case report. Medicine (Baltimore) 98, e17148.

Dinesh, K.P., Raniele, D., Michels, K., Avasare, R.S., Larsen, C.P., Kayton, R., Khalighi, M.A., and Andeen, N.K. (2019). Anti-LRP2 Nephropathy With Abundant IgG4-Positive Plasma Cells: A Case Report. Am J Kidney Dis 74, 132-137.

Dvanajscak, Z., Walker, P.D., Cossey, L.N., Messias, N.C., Boils, C.L., Kuperman, M.B., and Larsen, C.P. (2019). Hemolysis-associated hemoglobin cast nephropathy results from a range of clinicopathologic disorders. Kidney Int 96, 1400-1407.

Kuriakose, J., Redecke, V., Guy, C., Zhou, J., Wu, R., Ippagunta, S.K., Tillman, H., Walker, P.D., Vogel, P., and Häcker, H. (2019). Patrolling monocytes promote the pathogenesis of early lupus-like glomerulonephritis. J Clin Invest 129, 2251-2265.

Leung, N., Bridoux, F., Batuman, V., Chaidos, A., Cockwell, P., D’Agati, V.D., Dispenzieri, A., Fervenza, F.C., Fermand, J.P., Gibbs, S., et al. (2019). Publisher Correction: The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group. Nat Rev Nephrol 15, 121.

Leung, N., Bridoux, F., Batuman, V., Chaidos, A., Cockwell, P., D’Agati, V.D., Dispenzieri, A., Fervenza, F.C., Fermand, J.P., Gibbs, S., et al. (2019). The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group. Nat Rev Nephrol 15, 45-59.

Moledina, D.G., Wilson, F.P., Pober, J.S., Perazella, M.A., Singh, N., Luciano, R.L., Obeid, W., Lin, H., Kuperman, M., Moeckel, G.W., et al. (2019). Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis. JCI Insight 4.

Murphy, J.D., Joseph, M., and Larsen, C.P. (2019). Infantile Nephrocalcinosis Resulting From a Pathogenic CYP24A1 Mutation. Kidney Int Rep 4, 893-897.

Prema, K.S.J., Kurien, A.A., Gopalakrishnan, N., Walker, P.D., and Larsen, C.P. (2019). Dense deposit disease: a greatly increased biopsy incidence in India versus the USA. Clin Kidney J 12, 476-482.

Ravindran, A., Cortese, C., Larsen, C.P., Wadei, H.M., Gandhi, M.J., Cosio, F.G., and Sethi, S. (2019). Karyomegalic interstitial nephritis in a renal allograft. Am J Transplant 19, 285-290.

Skubitz, K.M., Wilson, J.D., Cheng, E.Y., Lindgren, B.R., Boylan, K.L.M., and Skubitz, A.P.N. (2019). Effect of chemotherapy on cancer stem cells and tumor-associated macrophages in a prospective study of preoperative chemotherapy in soft tissue sarcoma. J Transl Med 17, 130.

Tan, M., Hennigar, R.A., and Wolf, J.H. (2019). Post-Streptococcal Glomerulonephritis in Two Patients Following Deceased Donor Kidney Transplant. Am J Case Rep 20, 587-591.

Alexander, M.P., Dasari, S., Vrana, J.A., Riopel, J., Valeri, A.M., Markowitz, G.S., Hever, A., Bijol, V., Larsen, C.P., Cornell, L.D., et al. (2018). Congophilic Fibrillary Glomerulonephritis: A Case Series. Am J Kidney Dis 72, 325-336.

Ambruzs, J.M., and Larsen, C.P. (2018). Renal Manifestations of Inflammatory Bowel Disease. Rheum Dis Clin North Am 44, 699-714.

Dvanajscak, Z., Karl, B.E., Sanchez, A.P., and Walavalkar, V. (2018). IgA-Dominant Glomerulopathy and Thrombotic Microangiopathy After Chemotherapy. Kidney Int Rep 3, 492-497.

Gupta, A., Kuperman, M., and Shah, S. (2018). N-methylamphetamine (“Crystal Meth”)-Associated Acute Renal Cortical Necrosis. Kidney Int Rep 3, 1473-1476.

Larsen, C.P., Bonsib, S.M., Beggs, M.L., and Wilson, J.D. (2018). Fluorescence in situ hybridization for the diagnosis of NPHP1 deletion-related nephronophthisis on renal biopsy. Hum Pathol 81, 71-77.

Larsen, C.P., Wilson, J.D., Best-Rocha, A., Beggs, M.L., and Hennigar, R.A. (2018). Genetic testing of complement and coagulation pathways in patients with severe hypertension and renal microangiopathy. Mod Pathol 31, 488-494.

Raza, S.H., Sabghi, R., Kuperman, M., Postlethwaite, B., and Pattanaik, D. (2018). Management of ANCA-Associated Vasculitis in Pregnancy: Case Report and Review of the Literature. J Clin Rheumatol.

Selewski, D.T., Ambruzs, J.M., Appel, G.B., Bomback, A.S., Matar, R.B., Cai, Y., Cattran, D.C., Chishti, A.S., D’Agati, V.D., D’Alessandri-Silva, C.J., et al. (2018). Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN Study. Kidney Int Rep 3, 1373-1384.

Sharma, S.G., and Larsen, C.P. (2018). Tissue staining for THSD7A in glomeruli correlates with serum antibodies in primary membranous nephropathy: a clinicopathological study. Mod Pathol 31, 616-622.

Best Rocha, A., and Larsen, C.P. (2017). Membranous Glomerulopathy With Light Chain-Restricted Deposits: A Clinicopathological Analysis of 28 Cases. Kidney Int Rep 2, 1141-1148.

Cossey, L.N., Larsen, C.P., and Liapis, H. (2017). Collapsing glomerulopathy: a 30-year perspective and single, large center experience. Clin Kidney J 10, 443-449.

Hennigar, R.A., and Klein, C.L. (2017). Nephrotic Syndrome Post-Kidney Transplant. Clin J Am Soc Nephrol.

Kenan, D.J., Mieczkowski, P.A., Latulippe, E., Cote, I., Singh, H.K., and Nickeleit, V. (2017). BK Polyomavirus Genomic Integration and Large T Antigen Expression: Evolving Paradigms in Human Oncogenesis. Am J Transplant 17, 1674-1680.

Klein, J., Rodriguez, W., Kuperman, M., and Szerlip, H. (2017). Medullary angiitis and pauci-immune crescentic glomerulonephritis. Proc (Bayl Univ Med Cent) 30, 351-352.

Larsen, C.P., Trivin-Avillach, C., Coles, P., Collins, A.B., Merchant, M., Ma, H., Wilkey, D.W., Ambruzs, J.M., Messias, N.C., Cossey, L.N., et al. (2017). LDL receptor-related protein 2 (Megalin) as a target antigen in human kidney anti-brush border antibody disease. J Am Soc Nephrol 29.

Mutneja, A., Cossey, L.N., Liapis, H., and Chen, Y.M. (2017). A rare case of renal thrombotic microangiopathy associated with Castleman’s disease. BMC Nephrol 18, 57.

Boils, C.L., Aljadir, D.N., and Cantafio, A.W. (2016). Use of the PD-1 Pathway Inhibitor Nivolumab in a Renal Transplant Patient With Malignancy. Am J Transplant 16, 2496-2497.

Bonsib, S.M., Boils, C., Gokden, N., Grignon, D., Gu, X., Higgins, J.P., Leroy, X., McKenney, J.K., Nasr, S.H., Phillips, C., et al. (2016). Tuberous sclerosis complex: Hamartin and tuberin expression in renal cysts and its discordant expression in renal neoplasms. Pathology, research and practice 212, 972-979.

Colbert, G.B., Vankawala, P., Kuperman, M.B., and Mennel, R.G. (2016). Mammary-type myofibroblastoma with the nephrotic syndrome. Proc (Bayl Univ Med Cent) 29, 318-320.

Cossey, L.N., Hennigar, R.A., Bonsib, S., Gown, A.M., and Silva, F.G. (2016). Vascular mesangial channels in human nodular diabetic glomerulopathy. Hum Pathol 48, 148-153.

Kurien, A.A., Larsen, C.P., Rajapurkar, M., Bonsib, S.M., and Walker, P.D. (2016). Lack of electron microscopy hinders correct renal biopsy diagnosis: A study from India. Ultrastruct Pathol 40, 14-17.

Larsen, C.P., Beggs, M.L., Wilson, J.D., and Lathrop, S.L. (2016). Prevalence and organ distribution of leukocyte chemotactic factor 2 amyloidosis (ALECT2) among decedents in New Mexico. Amyloid 23, 119-123.

Larsen, C.P., Boils, C.L., Cossey, L.N., Sharma, S.G., and Walker, P.D. (2016). Clinicopathologic features of membranous-like glomerulopathy with masked IgG kappa deposits. Kidney Int Rep 1, 299-305.

Larsen, C.P., Cossey, L.N., and Beck, L.H. (2016). THSD7A staining of membranous glomerulopathy in clinical practice reveals cases with dual autoantibody positivity. Mod Pathol 29, 421-426.

Larsen, C.P., Durfee, T., Wilson, J.D., and Beggs, M.L. (2016). A Custom Targeted Next-Generation Sequencing Gene Panel for the Diagnosis of Genetic Nephropathies. Am J Kidney Dis 67, 992-993.

Larsen, C.P., Ismail, W., Kurtin, P.J., Vrana, J.A., Dasari, S., and Nasr, S.H. (2016). Leukocyte chemotactic factor 2 amyloidosis (ALECT2) is a common form of renal amyloidosis among Egyptians. Mod Pathol 29, 416-420.

Larsen, C.P., and Walker, P.D. (2016). The Authors Reply. Kidney Int 90, 225.

Liapis, H., Boils, C., Hennigar, R., and Silva, F. (2016). Myoglobin casts in renal biopsies: immunohistochemistry and morphologic spectrum. Hum Pathol 54, 25-30.

Lou, E., Schomaker, M., Wilson, J.D., Ahrens, M., Dolan, M., and Nelson, A.C. (2016). Complete and sustained response of adult medulloblastoma to first-line sonic hedgehog inhibition with vismodegib. Cancer Biol Ther 17, 1010-1016.

Sethi, S., Haas, M., Markowitz, G.S., D’Agati, V.D., Rennke, H.G., Jennette, J.C., Bajema, I.M., Alpers, C.E., Chang, A., Cornell, L.D., et al. (2016). Mayo Clinic/Renal Pathology Society Consensus Report on Pathologic Classification, Diagnosis, and Reporting of GN. J Am Soc Nephrol 27, 1278-1287.

Shah, P.B., Cooper, J.E., Lucia, M.S., Boils, C.L., Larsen, C.P., and Wiseman, A.C. (2016). APOL1 Polymorphisms in a Deceased Donor and Early Presentation of Collapsing Glomerulopathy and Focal Segmental Glomerulosclerosis in Two Recipients. Am J Transplant 16, 1923-1927.

Trpkov, K., Hes, O., Bonert, M., Lopez, J.I., Bonsib, S.M., Nesi, G., Comperat, E., Sibony, M., Berney, D.M., Martinek, P., et al. (2016). Eosinophilic, Solid, and Cystic Renal Cell Carcinoma: Clinicopathologic Study of 16 Unique, Sporadic Neoplasms Occurring in Women. The American journal of surgical pathology 40, 60-71.

Vincenti, F., Rostaing, L., Grinyo, J., Rice, K., Steinberg, S., Gaite, L., Moal, M.C., Mondragon-Ramirez, G.A., Kothari, J., Polinsky, M.S., et al. (2016). Belatacept and Long-Term Outcomes in Kidney Transplantation. N Engl J Med 374, 333-343.

Atta, M.G., Estrella, M.M., Skorecki, K.L., Kopp, J.P., Winkler, C.A., Wasser, W.G., Shemer, R., Racusen, L.C., Kuperman, M., Foy, M.C., et al. (2015). Association of APOL1 Genotype with Renal Histology among Black HIV-Positive Patients Undergoing Kidney Biopsy. Clin J Am Soc Nephrol 11.

Boils, C.L., Nasr, S.H., Walker, P.D., Couser, W.G., and Larsen, C.P. (2015). Update on endocarditis-associated glomerulonephritis. Kidney Int 87, 1241-1249.

Bonsib, S.M. (2015). Strategy for cystic kidney disease diagnosis Bonsib’s musings and notions. 1-16.

Han, K.H., Hennigar, R.A., and O’Neill, W.C. (2015). The association of bone and osteoclasts with vascular calcification. Vasc Med 20, 527-533.

Kenan, D.J., Mieczkowski, P.A., Burger-Calderon, R., Singh, H.K., and Nickeleit, V. (2015). The oncogenic potential of BK-polyomavirus is linked to viral integration into the human genome. J Pathol 237, 379-389.

Kurien, A.A., Larsen, C.P., and Cossey, L.N. (2015). Collagenofibrotic glomerulopathy. Clin Kidney J 8, 543-547.

Larsen, C.P., and Freedman, B.I. (2015). Apolipoprotein L1-associated nephropathy and the future of renal diagnostics. J Am Soc Nephrol 26, 1232-1235.

Larsen, C.P., Messias, N.C., Walker, P.D., Fidler, M.E., Cornell, L.D., Hernandez, L.H., Alexander, M.P., Sethi, S., and Nasr, S.H. (2015). Membranoproliferative glomerulonephritis with masked monotypic immunoglobulin deposits. Kidney Int 88, 867-873.

Messias, N.C., Walker, P.D., and Larsen, C.P. (2015). Paraffin immunofluorescence in the renal pathology laboratory: more than a salvage technique. Mod Pathol 28, 854-860.

Nasr, S.H., Dogan, A., and Larsen, C.P. (2015). Leukocyte Cell-Derived Chemotaxin 2–Associated Amyloidosis: A Recently Recognized Disease with Distinct Clinicopathologic Characteristics. Clin J Am Soc Nephrol, 1-10.

Nasr, S.H., Dogan, A., and Larsen, C.P. (2015). Leukocyte Cell-Derived Chemotaxin 2-Associated Amyloidosis: A Recently Recognized Disease with Distinct Clinicopathologic Characteristics. Clin J Am Soc Nephrol 10, 2084-2093.

O’Neill, W.C., Han, K.H., Schneider, T.M., and Hennigar, R.A. (2015). Prevalence of nonatheromatous lesions in peripheral arterial disease. Arterioscler Thromb Vasc Biol 35, 439-447.

Sis, B., Bagnasco, S.M., Cornell, L.D., Randhawa, P., Haas, M., Lategan, B., Magil, A.B., Herzenberg, A.M., Gibson, I.W., Kuperman, M., et al. (2015). Isolated endarteritis and kidney transplant survival: a multicenter collaborative study. J Am Soc Nephrol 26, 1216-1227.

Sugianto, J.Z., Stewart, B., Ambruzs, J.M., Arista, A., Park, J.Y., Cope-Yokoyama, S., and Luu, H.S. (2015). Applying the Principles of Lean Production to Gastrointestinal Biopsy Handling: From the Factory Floor to the Anatomic Pathology Laboratory. Lab Med 46, 259-264.

Vandergriff, T., Nezafati, K.A., Susa, J., Karai, L., Sanguinetti, A., Hynan, L.S., Ambruzs, J.M., Oliver, D.H., and Pandya, A.G. (2015). Defining early mycosis fungoides: validation of a diagnostic algorithm proposed by the International Society for Cutaneous Lymphomas. J Cutan Pathol 42, 318-328.