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Currently filtering by tag: Dermatomyositis

Fibrous Body

Fibrous Body, neuro path, arkana laboratories, Muscle biopsy
A 75-year-old female patient presents with proximal muscle weakness, characteristic skin rash, and dysphagia. Laboratory workup reveals elevated CPK 3500. A skeletal muscle biopsy is performed from the right thigh and shows findings diagnostic of dermatomyositis.  The muscle biopsy also shows rare vacuolated muscle fibers with Modified Gomori Trichrome stain.  Electron microscopy is pursued.  What is the ultrastructural finding seen in the electron photomicrograph shown below?   Answer: The electron photomicrograph shows a Fibrous (filamentous) body, which is a nonspecific finding that may be seen in a variety of clinical settings, including inflammatory myopathies, such as dermatomyositis, as well as...

Perifascicular Atrophy in Dermatomyositis

Perifascicular Atrophy, neuro notes, Arkana Laboratories, muscle biopsy
What histologic finding is observed in this case?         ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​   ​ ​     ​...