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Currently filtering by tag: Electron dense deposits

Fibronectin Glomerulopathy

A renal biopsy was performed in a 32-year-old female with microscopic hematuria and nephrotic range proteinuria of 4 grams per day. Serologic workup for autoimmune disease was negative. The glomeruli show extensive mesangial and subendothelial deposition of PAS-positive (A) and silver-negative material (B and C) by light microscopy. The immunofluorescence showed segmental glomerular staining for C3 (1-2+). An immunoperoxidase stain for fibronectin was diffusely positive in glomeruli (D) and electron microscopy showed massive electron dense deposits replacing the mesangium that were also present along the subendothelial aspect of basement membranes (E). These findings are consistent with fibronectin glomerulopathy. Approximately 40%...

Pushing Glass (May 16, 2017)

A 15-year-old boy had a kidney biopsy because of the persistent nephrotic syndrome. His medical history is significant for resolved intermittent asthma. In late September 2016, he developed a viral syndrome with a runny nose, congestion, sore throat, vomiting, and diarrhea. Over the next one to two weeks, he developed generalized edema, most prominent in the lower extremities and belly. He was diagnosed presumptively with acute glomerulonephritis and treated accordingly. His condition continued to worsen with the persistent nephrotic syndrome and acute hypertension. Laboratory investigations show a serum creatinine of 1.35 mg/dL. Serum albumin is 1.9 g/dL. Urinalysis shows 3+...