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Currently filtering by tag: EXT1

Twitter Poll (April 22, 2020)

Twitter Poll results for EXT1/EXT2
  ANSWER: A A recent study published by Sethi et al. demonstrated the presence of two proteins, Exostosin1 (EXT1) and Exostosin 2 (EXT2), along the GBM of PLA2R-negative MN. In this study, the authors showed that 81% of the EXT1/EXT2-associated MN showed features of autoimmune disease, including membranous lupus nephritis.   Reference: Sethi S, et al. Exostosin1/Exostosin 2-Associated Membranous Nephropathy. JASN 2019; 30:1123-1136.

Membranous Glomerulopathy Subtyping

Membranous Glomerulopathy Subtyping, Arkana Laboratories, Renal Pathology Teaching Points
The diagnosis of membranous glomerulopathy has evolved rapidly in the past 10 years since the identification of PLA2R as the major target antigen in primary membranous glomerulopathy. Today, rather than subtyping into vague categories such as 'primary' and 'secondary', we have tools available to name the specific type of disease present in most cases. Arkana Laboratories offers diagnostic testing for membranous glomerulopathy including immunohistochemical stains for tissue typing of PLA2R, THSD7A, EXT1/2, and NELL1 membranous and serum testing to monitor disease in patients with PLA2R and THSD7A-associated membranous glomerulopathy.