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This 22-year-old Caucasian female presented with acute renal failure and proteinuria five days after delivering her first child. The pregnancy was uneventful. Serum creatinine at presentation was 6.2 mg/dL (baseline of 0.8 mg/dL), hemoglobin 2.5 g/dL, platelets 22,000 and LDH 2300 U/L. The biopsy shows glomeruli with endocapillary fibrin thrombi, associated with segmental mesangiolysis and red blood cell fragmentation. These findings are diagnostic of a thrombotic microangiopathy (TMA). Numerous etiologies may lead to a TMA, all of which show morphologic overlap with no morphologic finding specific for a single etiology. Given the clinical history and the timing of disease presentation...