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Disease Week: Zebrafish Model Organism

Monday Introduction into zebrafish as a model organism Did you know? We have a state-of-the-art zebrafish facility here at Arkana Laboratories where we perform basic research with the goal of finding novel diagnostic and therapies for kidney diseases. https://www.arkanalabs.com/research/zebrafish/   Zebrafish (Danio rerio) is a small tropical fish native to South Asia that can be purchased from your local pet shop. Indeed, the first laboratory strains were derived from several pet shops in Oregon.   Traditionally, it has been a popular vertebrate model to study developmental biology due to its rapid development outside of the uterus and transparent embryos. https://dev.biologists.org/content/123/1/461...

Zebrafish: How Can They Help Us?

zebrafish, Arkana Laboratories research
Zebrafish: How Can They Help Us? I have enjoyed working with laboratory zebrafish since 2003.  Zebrafish have become a very well accepted model organism for human disease due to rapid breeding, fast development, transparent embryos, and conservation of 70% of human genes.  Several human diseases have been successfully modeled using zebrafish such as acute lymphoblastic leukemia, melanoma, and Duchenne muscular dystrophy. The majority of my time with these fish was spent in the Vanderbilt University system where I was involved in diverse research areas such as gastrulation, fetal alcohol syndrome, holoprosencephaly, Menkes Disease, and obesity. I discovered that I like...