arrow-right-realarrow-right-whitearrow-rightback-to-topdoctordownloadfacebookinstagramlogo-markerlogo-wordmarkpodcastsearchsearch_whitetwitter
Close Modal

Blog


Currently filtering by tag: zebrafish

Disease Week: Zebrafish Model Organism

Zebrafish first emerged over three decades ago as a promising animal model to better understand embryonic development in vertebrates. Recently, it has gained a foothold as a model to study human diseases and for drug discovery. Despite the vast amount of evolutionary time separating fish from humans, we share important similarities including most of our major organ systems as well as 70% of our genes. As such, many diseases can be modeled and studied in zebrafish. Unlike mammals, adult zebrafish have a nearly unparalleled regenerative capacity to replace and repair injured tissues including heart, spinal cord, and brain. Understanding how...

Zebrafish: How Can They Help Us?

I have enjoyed working with laboratory zebrafish since 2003.  Zebrafish have become a very well accepted model organism for human disease due to rapid breeding, fast development, transparent embryos, and conservation of 70% of human genes.  Several human diseases have been successfully modeled using zebrafish such as acute lymphoblastic leukemia, melanoma, and Duchenne muscular dystrophy. The majority of my time with zebrafish was spent in the Vanderbilt University system where I was involved in diverse research areas such as gastrulation, fetal alcohol syndrome, holoprosencephaly, Menkes Disease, and obesity. I discovered that I like contributing to the discovery or development of...