Answer: D, ALEC2
ALECT2 amyloidosis, or leukocyte chemotactic factor 2 amyloidosis makes up less than 10% of all cases of renal amyloidosis. This form of amyloidosis is classically seen in older individuals (~60 yrs.) and primarily affects individuals of Hispanic ancestry. Interestingly, while this form can be seen within glomeruli and vessels, it tends to have a propensity for interstitial deposition predominately within the cortex with sparing of the medulla. For more information, please see the following reference:
Larsen CP, Kossmann RJ, et al. Clinical, Morphologic, and Genetic Features of Renal Leukocyte Chemotactic Factor 2 Amyloidosis Kidney Int 2014;2:378-82.
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