July 8, 2021
Twitter Poll (July 7, 2021)
Which of the following types of amyloid is classically associated with Hispanic heritage and is characteristically found within the cortical interstitium with medullary sparing?
Answer: D) ALEC2
ALECT2 amyloidosis, or leukocyte chemotactic factor 2 amyloidosis makes up less than 10% of all cases of renal amyloidosis. This form of amyloidosis is classically seen in older individuals (~60 yrs.) and primarily affects individuals of Hispanic ancestry. Interestingly, while this form can be seen within glomeruli and vessels, it tends to have a propensity for interstitial deposition predominately within the cortex with sparing of the medulla. For more information, please see the following reference:
Larsen CP, Kossmann RJ, et al. Clinical, Morphologic, and Genetic Features of Renal Leukocyte Chemotactic Factor 2 Amyloidosis Kidney Int 2014;2:378-82.