September 9, 2021
Twitter Poll (September 9, 2021)
Which of the following membranous antigens has been recently identified and associated with underlying malignancy?
Answer: A) NELL1
NELL1, or neural epidermal growth factor-like 1 protein is a recently identified target antigen that has been associated with underlying malignancy in a subset of patients with membranous glomerulopathy. For further information, see references below.
Caza T, Hassen S, Dvanajscak Z, Kuperman M, et al. NELL1 is a target antigen in malignancy-associated membranous nephropathy. Kidney Int 2020 Aug 20:S0085-2538(20)30956-X.
Sethi S, Debiec H, Madden B, Charlesworth MC, et al. Neural epidermal growth factor-like 1 protein (NELL-1) associated membranous nephropathy. Kidney Int 2020 Jan;97(1):163-174.