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September 9, 2021

Twitter Poll (September 9, 2021)

NELL1

 

Which of the following membranous antigens has been recently identified and associated with underlying malignancy?

A) NELL1

B) PLA2R

C) EXT1/2

D) THSD7A

 

Answer: A) NELL1

NELL1, or neural epidermal growth factor-like 1 protein is a recently identified target antigen that has been associated with underlying malignancy in a subset of patients with membranous glomerulopathy. For further information, see references below.


References:

Caza T, Hassen S, Dvanajscak Z, Kuperman M, et al. NELL1 is a target antigen in malignancy-associated membranous nephropathy. Kidney Int 2020 Aug 20:S0085-2538(20)30956-X.

Sethi S, Debiec H, Madden B, Charlesworth MC, et al. Neural epidermal growth factor-like 1 protein (NELL-1) associated membranous nephropathy. Kidney Int 2020 Jan;97(1):163-174.