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How Times Have Changed! A Cornucopia of Antigens for Membranous Nephropathy
Membranous Nephropathy, or Membranous Glomerulopathy, is an autoimmune disease-causing nephrotic syndrome in which there is subepithelial deposition of IgG and…
Lipoic acid in neural epidermal growth factor-like 1-associated membranous nephropathy: More than a coincidence?
NELL1 is a recently described antigen seen in membranous glomerulopathy, which has been associated with malignancy. A recent study linked…
Transforming Growth Factor Beta Receptor 3 (TGFBR3)-Associated Membranous Nephropathy
Approximately half of lupus patients have kidney disease, including membranous glomerulopathy. On renal biopsy, immunofluorescence shows granular capillary loop deposits,…
Membranous Glomerulopathy
What is membranous glomerulopathy? Membranous glomerulopathyis a kidney disease that causes protein in the urine (proteinuria). In membranous glomerulopathy, immune…
Twitter Poll (September 9, 2021)
Answer: A, NELL1 NELL1, or neural epidermal growth factor-like 1 protein is a recently identified target antigen that has been…
Diagnose This (August 17, 2020)
What is your diagnosis for this patient with nephrotic syndrome? …
Resolving Membranous Nephropathy
A 40-year-old white male presents with 3 grams/24 hr of proteinuria and swelling around his ankles. He reports that he…
Membranous Lupus Nephritis
The patient is a 19-year-old female who presents with hematuria, nephrotic range proteinuria, and a creatinine of 1.2 mg/dL. She…
KDIGO Connections: Membranous Diagnosis Algorithm
Have you seen the latest proposed KDIGO algorithm for the diagnosis and treatment of membranous glomerulopathy? Dr. Bourne brings us…
Membranous Nephropathy After Transplantation
The biopsy shows a recurrent membranous nephropathy within a transplant. Figure 1 shows “spikes” and “holes.” Figure 2 shows mild…
Disease Week: Membranous Glomerulopathy
Monday History of MG Timeline of major discoveries in membranous glomerulopathy. Heymann nephritis was unique as a model of…
Twitter Poll (February 6, 2019)
Answer: B Minimal change disease is the most common glomerular disease associated with thymoma. Classically, the solid tumors most commonly…
KDIGO Connections: PLA2R-Positive Membranous Glomerulonephritis
KDIGO has some recommendations for anti-PLA2R testing in the research setting, but do you follow anti-PLA2R levels in your patients…
Art of Medicine: Membranous Glomerulopathy
The painting above depicts membranous glomerulopathy. A single glomerular capillary loop with confluent subepithelial and intramembranous electron dense deposits along…
KDIGO Connections: Membranous Glomerulopathy
Welcome to the first post in our new series KDIGO Connections, a series in which we are asking our nephrologist…