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How Times Have Changed! A Cornucopia of Antigens for Membranous Nephropathy
Membranous glomerulopathy is an autoimmune disease-causing nephrotic syndrome in which there is subepithelial deposition of IgG and complements along the…
Lipoic acid in neural epidermal growth factor-like 1-associated membranous nephropathy: More than a coincidence?
NELL1 is a recently described antigen seen in membranous glomerulopathy, which has been associated with malignancy. A recent study linked…
Transforming Growth Factor Beta Receptor 3 (TGFBR3)-Associated Membranous Nephropathy
Approximately half of lupus patients have kidney disease, including membranous glomerulopathy. On renal biopsy, immunofluorescence shows granular capillary loop deposits,…
Twitter Poll (September 9, 2021)
Answer: A, NELL1 NELL1, or neural epidermal growth factor-like 1 protein is a recently identified target antigen that has been…
Diagnose This (August 17, 2020)
What is your diagnosis for this patient with nephrotic syndrome? …
Resolving Membranous Nephropathy
A 40-year-old white male presents with 3 grams/24 hr of proteinuria and swelling around his ankles. He reports that he…
Membranous Lupus Nephritis
The patient is a 19-year-old female who presents with hematuria, nephrotic range proteinuria, and a creatinine of 1.2 mg/dL. She…
KDIGO Connections: Membranous Diagnosis Algorithm
Have you seen the latest proposed KDIGO algorithm for the diagnosis and treatment of membranous glomerulopathy? Dr. Bourne brings us…
Membranous Nephropathy After Transplantation
The biopsy shows a recurrent membranous nephropathy within a transplant. Figure 1 shows “spikes” and “holes.” Figure 2 shows mild…
Disease Week: Membranous Glomerulopathy
Monday History of MG Timeline of major discoveries in membranous glomerulopathy. Heymann nephritis was unique as a model of…
Twitter Poll (February 6, 2019)
Answer: B Minimal change disease is the most common glomerular disease associated with thymoma. Classically, the solid tumors most commonly…
KDIGO Connections: PLA2R-Positive Membranous Glomerulonephritis
KDIGO has some recommendations for anti-PLA2R testing in the research setting, but do you follow anti-PLA2R levels in your patients…
Art of Medicine: Membranous Glomerulopathy
The painting above depicts membranous glomerulopathy. A single glomerular capillary loop with confluent subepithelial and intramembranous electron dense deposits along…
KDIGO Connections: Membranous Glomerulopathy
Welcome to the first post in our new series KDIGO Connections, a series in which we are asking our nephrologist…
Membranous Glomerulopathy in Obesity-Related Glomerulopathy
The patient is a 57-year-old female, with a history of morbid obesity and persistent mild proteinuria (approximately 1 gm), who…
