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Chronic Active Antibody Mediated Rejection

By Joel Murphy, MD

Aug 26, 2022

Chronic Active Antibody Mediated Rejection

Welcome back to another episode of Banff and Beyond. In this episode, Dr. Murphy discusses a transplant biopsy showing overt glomerulitis, peritubular capillaritis, and diffusely positive C4d staining as well as occasional double contour formation, compatible with chronic active antibody-mediated rejection. Of note, the patient was also known to have positive donor specific antibodies. Importantly, the biopsy did not show significant interstitial inflammation or overt tubulitis and thus did not demonstrate a component of concomitant T cell-mediated rejection.



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