Diagnose This (April 4, 2022)
This is the biopsy of a 62yo Hispanic female with hematuria and proteinuria. What is this stain and what is the diagnosis?
The stain is a Congo Red viewed under fluorescent light with a red filter. It highlights interstitial amyloid deposits, which is the predominant pattern of deposition in LECT2 amyloidosis (confirmed by IHC stain, Figure 2). There were also mesangial IgA deposits (Figure 3), which likely explain the patient’s hematuria and proteinuria, since there was very little glomerular amyloid (Figure 4).
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