Back to Blog

Diagnose This (August 8, 2022)

Clarissa Cassol, MD renal pathologist at arkana laboratories
By Clarissa Cassol, MD

Aug 09, 2022

chronic antibody mediated rejection, peritubular capillary basement membrane multilayering

In a renal allograft, what is your diagnosis given these ultrastructural findings?


The EM picture shows glomerular basement membrane multilayering, which is consistent with chronic antibody mediated rejection. There was also peritubular capillary basement membrane multilayering, although no greater than 7 layers (Figures 2 and 3). By light microscopy, glomerulitis and peritubular capillaritis were also present. The patient had a previous biopsy, two years prior, that had already shown ABMR.


Quick note: This post is to be used for informational purposes only and does not constitute medical or health advice. Each person should consult their own doctor with respect to matters referenced. Arkana Laboratories assumes no liability for actions taken in reliance upon the information contained herein.