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Diagnose This (December 21, 2020)

Joel Murphy, MD
By Joel Murphy, MD

Dec 22, 2020

renal argyria, arkana laboratories, renal pathology, kidney

What is your diagnosis in a patient with a particular “gray” appearance to their complexion?

 

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Answer: The light microscopic image of a glomerulus on H&E stain depicts numerous black deposits along glomerular basement membranes and mesangium characteristic of renal argyria. Argyria is a systemic disease caused by the deposition and accumulation of silver or silver salts classically through ingestion. The deposition within the skin and conjunctiva lead to a characteristic “slate grey” complexion. By electron microscopy, glomeruli demonstrate characteristic opaque deposits along glomerular basement membranes predominately along the subendothelial aspect. Of note, an attuned pathologist can suspect this diagnosis even at the grossing bench as the biopsy will show classic “black” glomeruli under the dissecting scope due to the silver deposition.   

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Quick note: This post is to be used for informational purposes only and does not constitute medical or health advice. Each person should consult their own doctor with respect to matters referenced. Arkana Laboratories assumes no liability for actions taken in reliance upon the information contained herein.