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Diagnosis This 1/15/2024

By Joel Murphy, MD

Jan 15, 2024

What considerations should be included in your differential diagnosis given the provided histologic finding?

The image of a Jones silver stain depicts a small vessel within the center of the image along with a surrounding, somewhat well-formed non-necrotizing granuloma with associated touton giant cell (approximately 4-5 o’clock). The most common consideration to include in your differential for granulomatous tubulointerstitial nephritis is drug/hypersensitivity reaction.

However, other considerations would also include underlying infection (particularly mycobacterial or fungal), autoimmune disease, as well as sarcoidosis (diagnosis of exclusion).


Quick note: This post is to be used for informational purposes only and does not constitute medical or health advice. Each person should consult their own doctor with respect to matters referenced. Arkana Laboratories assumes no liability for actions taken in reliance upon the information contained herein.