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December 10, 2020

Grouped Atrophy

grouped atrophy, neuro notes, neuropathology

This skeletal muscle biopsy shows grouped atrophy, which is a finding characteristic of denervation.  This morphologic alteration indicates the presence of prior denervation and subsequent successful re-innervation.  The surrounding muscle fibers often show enlarged least mean fiber diameter due to compensatory hypertrophy.  (Image:  Hematoxylin and eosin-stained frozen section, 400x magnification)