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Denervated Neuromuscular Junctions
Clinical History:Muscle biopsy from this 40-year-old patient showed morphologic and enzyme histochemical features of denervation.What abnormality is seen in the…
Vacuolar myopathy in 92-year-old male
Clinical History:The patient is a 92-year-old-male and presented progressive muscle weakness that began in the left upper extremity and spread…
Lateral Upper Thigh Mass
Clinical HistoryThis 50-year-old patient presented with a chronic lateral upper thigh mass which appeared to arise from the tensor fascia…
Denervation
This 66-year-old patient presented with complaints of asymmetric distal lower extremity weakness. Their past medical history was significant for atrial…
Succinic Acid Dehydrogenase
This 60 year-old patient presented with distal asymmetric muscle weakness and normal CPK. Which of the following abnormalities is well-demonstrated in…
Target Fibers On Trichrome
This 40-year-old patient presented with complaints of leg cramps, lower extremity muscle weakness, and loss of muscle mass. Laboratory studies…
Grouped Atrophy
This skeletal muscle biopsy shows grouped atrophy, which is a finding characteristic of denervation. This morphologic alteration indicates the presence…
Exocytosis in a Skeletal Muscle Biopsy
This electron micrograph of two adjacent skeletal muscle cells demonstrates simultaneous exocytosis. Exocytosis in this case shows extravasation of lysosomes…