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Jon Wilson, MD neuropathologist at arkana laboratories
By Jon Wilson, MD

Sep 02, 2022

denervation (neurogenic atrophy)

This 66-year-old patient presented with complaints of asymmetric distal lower extremity weakness. Their past medical history was significant for atrial fibrillation, coronary artery disease, hyperlipidemia, hypertension, ischemic cardiomyopathy, prior myocardial infarction, and type 2 diabetes. Laboratory studies showed mild elevation of CPK. On physical examination they were noted to have loss of sensation in a stocking-like distribution.

Based on figures #1 – #5 what is your diagnosis?

A. Polymyositis

B. Type 2 atrophy

C. Vasculitis

D. Denervation



Answer: Denervation

The morphologic features seen in the figures are those of denervation (neurogenic atrophy). Denervation may occur in the setting of peripheral neuropathy, radiculopathy, and motor neuron disease.




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