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Necrotic Myofibers

Jon Wilson, MD neuropathologist at arkana laboratories
By Jon Wilson, MD

Nov 04, 2022

This 20-year-old patient presented with acute onset muscle weakness and numbness. Laboratory studies showed elevated CPK (4000) and negative toxin/drug screen. The patient was treated with steroid prior to muscle biopsy.


How would you characterize the abnormal muscle fibers seen in figures #1 – #3?

A. Normal

B. Necrotic

C. Lobulated

D. Acutely angulated


Correct Answer: Necrotic

These represent necrotic muscle fibers. In this case all of the damaged myofibers had a similar appearance suggesting acute monophasic injury.


Quick note: This post is to be used for informational purposes only and does not constitute medical or health advice. Each person should consult their own doctor with respect to matters referenced. Arkana Laboratories assumes no liability for actions taken in reliance upon the information contained herein.