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Neuromuscular Junction Thick Section

Jon Wilson, MD neuropathologist at arkana laboratories
By Jon Wilson, MD

Sep 23, 2022

This 60-year-old patient presented with muscle weakness and ptosis. Laboratory studies reported normal CPK and negative myositis autoantibody panel. Myasthenia gravis autoantibody panel (AChR, MuSK and LRP4) was negative.

 

 

What are the structures indicated by the arrows in Figure #1?

A.Satellite cell

B.Neuromuscular junction

C.Muscle spindle

D.Golgi tendon organ

 

 

Answer: Neuromuscular Junction

This high magnification image shows a semilunar area containing two adjacent neuromuscular junctions (black arrows).  The oval to round paler areas represent the axon terminal.  In this image the motor endplate has an appearance reminiscent of thin flower petals (undulating post-synaptic membrane).

Note the myelinated axons seen in the small nerve twig within the endomysium (white arrow).

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