Muscle biopsy was performed on this 40-year-old patient who presented with proximal lower extremity muscle weakness and normal CPK.
What is the structure demonstrated in Figure #1?
B. Pacinian corpuscle
C. Neuromuscular junction
Answer: Neuromuscular Junction
The image shows the components of the neuromuscular junction (AKA myoneural junction). The undulating motor endplate serves to increase the surface area of the post-synaptic membrane.
The region of the motor endplate typically shows associated muscle fiber nuclei and mitochondria.
Reference(s) / additional reading:
Braz LP, Ng YS, Gorman GS, Schaefer AM, McFarland R, Taylor RW, Turnbull DM, Whittaker RG. Neuromuscular Junction Abnormalities in Mitochondrial Disease: An Observational Cohort Study. Neurol Clin Pract. 2021 Apr;11(2):97-104. doi: 10.1212/CPJ.0000000000000795. PMID: 33842062; PMCID: PMC8032443.
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