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Perifascicular Necrosis

Jon Wilson, MD neuropathologist at arkana laboratories
By Jon Wilson, MD

Oct 14, 2022

This 60-year-old patient presented with progressive proximal upper and lower extremity muscle weakness of two months duration.


Which of the following terms best describes the morphologic alterations?

A. Ragged red fibers

B. Perifascicular necrosis

C. Acutely angulated

D. Normal biopsy



Correct Answer: Perifascicular necrosis

The presence of necrotic and regenerating muscle fibers in a perifascicular distribution is categorized as perifascicular necrosis. A perifascicular pattern of muscle fiber injury may be seen patient’s with dermatomyositis and anti-synthetase syndrome.




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