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Effects Of Neurosteroid Actions At N-Methyl-D-Aspartate And Gaba A Receptors In The Midbrain Ventral Tegmental Area For Anxiety-Like And Mating Behavior Of Female Rats
In the midbrain ventral tegmental area (VTA), actions of neurosteroids, such as the progesterone metabolite, 5-pregnan-3-ol-20-one (3,5-THP), can facilitate mating…
Nonsteroidal Anti-Inflammatory Drugs Are Associated With Increased Neuritic Plaques
Observational and experimental studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) may protect against Alzheimer disease (AD); however, clinical trials and…
A Novel Mutation In FHL1 In A Family With X-Linked Scapuloperoneal Myopathy: Phenotypic Spectrum And Structural Study Of FHL1 Mutations
An X-linked myopathy was recently associated with mutations in the four-and-a-half-LIM domains 1 (FHL1) gene. We identified a family with…
Conjugated Equine Estrogen, With Medroxyprogesterone Acetate, Enhances Formation Of 5alpha-Reduced Progestogens And Reduces Anxiety-Like Behavior Of Middle-Aged Rats
The mechanisms by which progestogens influence affective behaviors in females are poorly understood despite clear changes in mood/affect that are…
Pathologic Correlates Of Dementia In Individuals With Lewy Body Disease
Cognitive impairment and dementia are more common in patients with Parkinson disease (PD) than age-matched controls and appear to become…
Quantitative Proteomic Analysis Of Oligodendrogliomas With And Without 1p/19q Deletion
Approximately 50-80% of oligodendrogliomas demonstrate a combined loss of chromosome 1p and 19q. Chromosome 1p/19q deletion, appearing early in tumorigenesis,…
Association Between Lifetime Cigarette Smoking And Lewy Body Accumulation
Cigarette smoking has been associated repeatedly in observational studies with decreased risk of Parkinson’s disease (PD), but its relationship to…
Cerebrospinal Fluid Biomarkers In Mild Cognitive Impairment And Dementia
Given the magnitude of the public health problem of dementia in the elderly, there is a pressing need for research,…
Low Doses Of Cocaine Decrease, And High Doses Increase, Anxiety-Like Behavior And Brain Progestogen Levels Among Intact Rats
There are sex and hormonal differences in response to cocaine that have been demonstrated in people and animal models. Cocaine…
Elevated Ratio Of Urinary Metabolites Of Thromboxane And Prostacyclin Is Associated With Adverse Cardiovascular Events In Adapt
Results from prevention trials, including the Alzheimer’s Disease Anti-inflammatory Prevention Trial (ADAPT), have fueled discussion about the cardiovascular (CV) risks…
Glatiramer Acetate Immune System Augmentation For Peripheral Nerve Regeneration In Rat Crushed Sciatic Nerve Model
Protective antiself response to nervous system injury has been reported to be mediated by a T-cell subpopulation that can recognize…
Sex Differences In Salivary Cortisol In Response To Acute Stressors Among Healthy Participants, In Recreational Or Pathological Gamblers, And In Those With Posttraumatic Stress Disorder
Sex differences in incidence and severity of some stress-related, neuropsychiatric disorders are often reported to favor men, suggesting that women…
Neuropathology In The Adult Changes In Thought Study: A Review
The neuropathology underlying dementia syndromes in older populations is complex. The contributions of Alzheimer’s and Lewy body pathology are well…
Blood Pressure And Brain Injury In Older Adults: Findings From A Community-Based Autopsy Study
The presence of more than 2 microinfarcts, but not any other pathological change, was independently associated with SBP in younger…
Male Gamblers Have Significantly Greater Salivary Cortisol Before And After Betting On A Horse Race, Than Do Female Gamblers
Prevalence rates of gambling are influenced by gender. Among normative populations, hypothalamic-pituitary-adrenal (HPA) axis response to stress is affected by…