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Chronic Estradiol Replacement To Aged Female Rats Reduces Anxiety-Like And Depression-Like Behavior And Enhances Cognitive Performance
Decline in the ovarian steroid, estradiol (E(2)), with the menopause transition may influence cognitive and affective processing of older women…
Infusions Of Bicuculline To The Ventral Tegmental Area Attenuates Sexual, Exploratory, And Anti-Anxiety Behavior Of Proestrous Rats
Actions of 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP), in the midbrain ventral tegmental area (VTA) modulate sexual receptivity of female rats. Actions of 3alpha,5alpha-THP…
Associations Between Microinfarcts And Other Macroscopic Vascular Findings On Neuropathologic Examination In 2 Databases
Clinicians may undervalue brain microinfarcts because they are defined by neuropathology and not seen on magnetic resonance imaging (MRI). We…
Gambling Pathology Is Associated With Dampened Cortisol Response Among Men And Women
Pathological gambling has many similarities to pharmacological addiction. Notably, both pathological gambling and drug addiction are characterized by aberrations in…
Different Patterns Of Cerebral Injury In Dementia With Or Without Diabetes
Diabetes mellitus (DM) increases the risk of dementia in the elderly. However, its underlying mechanisms, its connection with Alzheimer disease…
The Renal Biopsy
The first renal biopsy was carried out more than a century ago, but its widespread introduction into clinical use, beginning…
Free Radical Damage To Cerebral Cortex In Alzheimer’s Disease, Microvascular Brain Injury, And Smoking
Evidence supports a pathogenic role for free radical injury to brain in Alzheimer’s disease; however, clinical trial results are only…
Neuropathology-Based Risk Scoring For Dementia Diagnosis In The Elderly
Current neuropathologic consensus criteria for diagnosis of dementia yield a classification of processes that likely contributed to dementia in that…
Adjustment For Selection Bias In Observational Studies With Application To The Analysis Of Autopsy Data
The interpretation of neuropathological studies of dementia and Alzheimer’s disease is complicated by potential selection mechanisms that can drive whether…
Nociceptive And Anxiety-Like Behavior In Reproductively Competent And Reproductively Senescent Middle-Aged Rats
Changes in levels of estradiol and progesterone that occur with the transition to reproductive senescence may influence nociception or affect.
Alcohol Dose-Dependently Enhances 3α-Androstanediol Formation In Frontal Cortex of Male Rats Concomitant with Aggression
Alcohol (EtOH) can enhance aggression in people and animal models. These effects are more salient in males than in females.…
Increasing 3alpha,5alpha-Thp Following Inhibition Of Neurosteroid Biosynthesis In The Ventral Tegmental Area Reinstates Anti-Anxiety, Social, And Sexual Behavior Of Naturally Receptive Rats
The progesterone metabolite and neurosteroid, 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP), has actions in the midbrain ventral tegmental area (VTA) to modulate lordosis, but…
Estrogen Is Necessary For 5α-Pregnan-3α-ol-20-One (3α,5α-THP) Infusion To The Ventral Tegmental Area To Facilitate Social And Sexual, But Neither Exploratory Nor Affective Behavior Of Ovariectomized Rats
The progesterone metabolite, 5-pregnan-3-ol-20-one (3,5-THP, allopregnanolone), acts in the ventral tegmental area (VTA) to facilitate exploratory, anti-anxiety, and socio-sexual behavior…
Biomarkers For Cognitive Impairment And Dementia In Elderly People
The threat of a looming pandemic of dementia in elderly people highlights the compelling need for the development and validation…
Exploratory, Anti-Anxiety, Social, And Sexual Behaviors Of Rats In Behavioral Estrus Is Attenuated With Inhibition Of 3α,5α-Thp Formation In The Midbrain Ventral Tegmental Area
The progesterone (P4) metabolite and neurosteroid, 5-pregnan-3-ol-20-one (3,5-THP) acts in the midbrain ventral tegmental area (VTA) to modulate lordosis of…