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Zebrafish Research

A powerful and convenient model organism, the zebrafish provides a deep toolbox for investigators in basic and applied biomedical research.

Arkana Zebrafish Core Program

We offer personalized customer services which include transgenic model development and preclinical toxicity/efficacy evaluation using the zebrafish model system.

Zebrafish are vertebrates that share more than 90% gene homology with humans, including 85% of known disease-causing genes. They have several organ systems that are anatomically and functionally similar to humans. The zebrafish model system provides accurate, timely and cost-effective information when compared with conventional in vitro assays and traditional animal models.

Services

Transgenic Zebrafish

Using the latest CRISPR technology, we work with customers to create unique transgenic zebrafish models that deliver study-ready cohorts and meet their research requirements. Our scientists provide personalized assistance to customers in the creation and development of specialized disease models. Line maintenance and curation is offered as part of this service.

 

ToxScreen

The ToxScreen is a 96 hour assay performed using minimal amounts of test article to determine organotoxicity. Since zebrafish embryos are permeable to water-soluble and DMSO solubilized test articles, the ToxScreen provides confident results while saving time and money. Test articles are provided by the investigator or study sponsor.

 

OncoScreen

The OncoScreen is a 96 hour zebrafish embryo xenotransplantation assay assessing drug effects on the growth and metastasis of human tumor cells. It allows prediction of individual cancer patient responses to therapy. Patient-derived tumor cells or cultured tumor cells are provided by the investigator or clinician.

 

Individual investigators

If you wish to use the zebrafish model system but do not have convenient access, we offer developmentally staged embryos, adult zebrafish and rack rentals. Our current zebrafish lines include 5D, AB, TU, and Casper.

For more information contact aquaticsservices@arkanalabs.com

Why zebrafish?

Vertebrate: shares all major organ systems with mammals.
High genetic homology with humans: 85% similarity.
Easy manipulation: external fertilization and embryogenesis.
High productivity: 200-1000 embryos per mating pair per week.
Easy to study: transparent embryos.
Short generation time: 6-8 weeks.
Amounts of compound to be screened are very small.
Rapid organogenesis, with access to all stages of development.
Short experiment duration (3-5 days).
Fewer ethical impediments as compared to other animal models.