Clinical History:
The patient is a 37-year-old with multiple dural based masses.
What hematologic condition is rarely associated with this specific subtype of this tumor type?
A. Large B-Cell Lymphoma
B. Erdheim-Chester Disease
C. Castleman Disease
D. Red Cell Aplasia
Answer:
C. Castleman Disease
The histology demonstrates a tumor comprised of vacuolated epithelioid and spindled cells embedded in a mucin-rich matrix. SSTR2 is strongly positive and the patient has a history of multiple dural based lesions. The findings are consistent with a chordoid meningioma. Chordoid meningiomas often demonstrate 2p chromosomal deletions and are rarely associated with Castleman disease.
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