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MGRS, Monoclonal gammopathy of renal significance, arkana laboratories, pathology of the kidney
Twitter Poll

Twitter Poll (December 7, 2018)

ANSWER: D MGRS was introduced to acknowledge a clonal plasma cell or B lymphocyte proliferation causing a renal lesion in…

By Vanessa Moreno, MD
IgG4-related disease
Diagnose This!

Diagnose This (September 10, 2018)

What is your diagnosis? This biopsy shows a chronic, active tubulointerstitial nephritis with sharp demarcation between affected and non-affected tissue…

By L. Nich Cossey, MD
IgG4-Related Tubulointerstitial Nephritis
Teaching Points

IgG4-Related Tubulointerstitial Nephritis

IgG4-related disease is a systemic inflammatory and sclerosing disorder which may affect a wide range of different organs including the…

Sjogrens Syndrome
Teaching Points


Sjgrens syndrome is an autoimmune disease involving primarily the lacrimal and salivary glands. However, up to 27% of patients will…

(CIN) Chronic Interstitial Nephritis
Teaching Points

Chronic Interstitial Nephritis

Chronic interstitial nephritis is a diagnosis made on renal biopsy when interstitial inflammation is present in a background of fibrosis…

IgG4-Positive Plasma Cells
Teaching Points


Renal parenchyma with florid interstitial fibrosis with thick bands of sclerosis expanding the interstitium and pushing the tubules apart on…