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September 14, 2017
Sjogrens

- Published: September 14, 2017
- By: Chris Larsen, MD and Arkana Author
- Tags: Acute kidney injury, Chronic kidney disease, Interstitial nephritis, Plasma cells, Progressive renal failure, Sjorgrens syndrome
Sjögren’s syndrome is an autoimmune disease involving primarily the lacrimal and salivary glands. However, up to 27% of patients will also have renal involvement. When clinical evidence of renal involvement is present, approximately 71% show evidence of interstitial nephritis on biopsy including 46% with chronic interstitial nephritis and 25% with acute interstitial nephritis. On renal biopsy, the inflammatory infiltrates in Sjögren’s-related interstitial nephritis (as shown here) is typically mononuclear and rich in plasma cells. Unlike the interstitial nephritis was seen with IgG4-related disease or lupus, there are no tubular basement membrane deposits present by immunofluorescence.