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Sjogrens

Chris Larsen, MD renal pathologist at arkana laboratories
By Chris Larsen, MD

Sep 14, 2017

Sjogrens Syndrome

Sjögren’s syndrome is an autoimmune disease involving primarily the lacrimal and salivary glands. However, up to 27% of patients will also have renal involvement. When clinical evidence of renal involvement is present, approximately 71% show evidence of interstitial nephritis on biopsy including 46% with chronic interstitial nephritis and 25% with acute interstitial nephritis. On renal biopsy, the inflammatory infiltrates in Sjögren’s-related interstitial nephritis (as shown here) is typically mononuclear and rich in plasma cells. Unlike the interstitial nephritis was seen with IgG4-related disease or lupus, there are no tubular basement membrane deposits present by immunofluorescence.

Sjögren’s-related interstitial nephritis

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Quick note: This post is to be used for informational purposes only and does not constitute medical or health advice. Each person should consult their own doctor with respect to matters referenced. Arkana Laboratories assumes no liability for actions taken in reliance upon the information contained herein.