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Resistant Starch Slows the Progression of CKD in the 5/6 Nephrectomy Mouse Model
In patients with chronic kidney disease, toxins normally excreted by the kidney continue to circulate, leading to increased kidney damage.…
What is Chronic Kidney Disease?
Chronic Kidney Disease (CKD) Chronic Kidney Disease(CKD) is the gradual loss of kidney function over time. Over 26 million Americans…
Twitter Poll: October 30, 2019
ANSWER: D, All of the Above ADPKD is the most common inherited kidney disorder. Two genes PKD1 and PKD2, coding…
Twitter Poll (September 26, 2019)
ANSWER: C, Black APOL1-risk alleles have been reported only on African-derived chromosomes, including individuals from West Africa and recently admixed…
KDIGO Connections: Fibrillary Glomerulopathy
If you have taken care of patients with fibrillary glomerulopathy, what has been the outcome?
Twitter Poll (May 22, 2019)
ANSWER: C By the Oxford Classification of IgA nephropathy, the findings present are classified as “M1 E1 S1 T1 C0”…
Crescentic IgA nephropathy
Focal crescentic IgA nephropathy The patient is a 17-year-old white female who presents with 2.85 grams/24 hr proteinuria, microscopic hematuria,…
Twitter Poll (January 16, 2019)
ANSWER: B The target of the circulating ABBA autoantibodies is LDL receptor-related protein 2 (LRP2) also known as Megalin. ABBA…
Disease Week: Fibrillary Glomerulopathy
Monday Did you know Fibrillary Glomerulopathy was described in the 1980s? While case reports existed before, in 1983 a series…
Twitter Poll (January 9, 2019)
ANSWER: C- DNAJB9 DNAJB9 immunohistochemical (IHC) stain is a quick and inexpensive tool used to confirm the diagnosis of Fibrillary…
Art of Medicine: Uromodulin
Welcome to our first post in the Art of Medicine series! In the hustle and bustle of busy clinics, labs,…
Where is the normal kidney tissue?
This kidney biopsy shows the histologic features characteristic of malakoplakia, which includes a dense, often obliterative, inflammatory infiltrate rich in…
DNAJB9 helps uncover dual pathology…
This case illustrates the utility of immunohistochemical staining for DNAJB9, a recently described biomarker for fibrillary glomerulopathy (see reference). The…
Not Quite Nodular
This biopsy came from a 70-year-old gentleman with acute renal failure. He had a known history of diabetes, hypertension, and…
Membranous Glomerulopathy in Obesity-Related Glomerulopathy
The patient is a 57-year-old female, with a history of morbid obesity and persistent mild proteinuria (approximately 1 gm), who…
