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NCAM1, Membranous Nephropathy, Lipoic Acid in NELL1-Associated Membranous Nephropathy, SARS-CoV-2, biopsy, TGFBR3, crystalline nephropathies, Renal Intratubular Casts, viral-like inclusions, Covid-19, Anti-Brush Border Antibody Disease, MGMID, renal pathology, kidney research

Resistant Starch Slows the Progression of CKD in the 5/6 Nephrectomy Mouse Model

In patients with chronic kidney disease, toxins normally excreted by the kidney continue to circulate, leading to increased kidney damage.…

By Dr. Rebecca May
What is Chronic Kidney Disease illustration for patient resources
Patient Resources

What is Chronic Kidney Disease?

Chronic Kidney Disease (CKD) Chronic Kidney Disease(CKD) is the gradual loss of kidney function over time. Over 26 million Americans…

ADPKD, PKD1 and PKD2, Twitter Poll, Arkana Laboratories
Twitter Poll

Twitter Poll: October 30, 2019

ANSWER: D, All of the Above ADPKD is the most common inherited kidney disorder. Two genes PKD1 and PKD2, coding…

By Vanessa Moreno, MD

APOL1 Risk Variants, Twitter Poll, renal disease, arkana laboratories
Twitter Poll

Twitter Poll (September 26, 2019)

ANSWER: C, Black APOL1-risk alleles have been reported only on African-derived chromosomes, including individuals from West Africa and recently admixed…

By Vanessa Moreno, MD
KDIGO Connections

KDIGO Connections: Fibrillary Glomerulopathy

If you have taken care of patients with fibrillary glomerulopathy, what has been the outcome?      

IgA nephropathy, Twitter Poll, Arkana Laboratories, kidney pathology, renal disease
Twitter Poll

Twitter Poll (May 22, 2019)

ANSWER: C By the Oxford Classification of IgA nephropathy, the findings present are classified as “M1 E1 S1 T1 C0”…

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focal fibrinoid necrosis, IgA, Crescentic IgA Nephropathy, chronic kidney disease, Arkana Laboratories
Teaching Points

Crescentic IgA nephropathy

Focal crescentic IgA nephropathy The patient is a 17-year-old white female who presents with 2.85 grams/24 hr proteinuria, microscopic hematuria,…

ABBA (Anti-Brush Border Antibody Disease), twitter poll, arkana laboratories, renal pathology
Twitter Poll

Twitter Poll (January 16, 2019)

ANSWER: B The target of the circulating ABBA autoantibodies is LDL receptor-related protein 2 (LRP2) also known as Megalin. ABBA…

By Vanessa Moreno, MD
Disease Week

Disease Week: Fibrillary Glomerulopathy

Monday Did you know Fibrillary Glomerulopathy was described in the 1980s? While case reports existed before, in 1983 a series…

By L. Nich Cossey, MD

DNAJB9 histo stain, renal pathology, arkana laboratories, pathology
Twitter Poll

Twitter Poll (January 9, 2019)

ANSWER: C- DNAJB9 DNAJB9 immunohistochemical (IHC) stain is a quick and inexpensive tool used to confirm the diagnosis of Fibrillary…

By Vanessa Moreno, MD
uromodulin, Art of Medicine
Art of Medicine

Art of Medicine: Uromodulin

Welcome to our first post in the Art of Medicine series! In the hustle and bustle of busy clinics, labs,…

Malakoplakia, renal pathology, arkana laboratories
Teaching Points

Where is the normal kidney tissue?

This kidney biopsy shows the histologic features characteristic of malakoplakia, which includes a dense, often obliterative, inflammatory infiltrate rich in…

DNAJB9 Uncovers Dual Pathology
Teaching Points

DNAJB9 helps uncover dual pathology…

This case illustrates the utility of immunohistochemical staining for DNAJB9, a recently described biomarker for fibrillary glomerulopathy (see reference). The…

ANCA Disease, LECT2 Amyloid, IgG4-Related Disease, AL amyloidosis, ANCA, digging deeper, Dr. Messias, Arkana Laboratories, pathology diseases
Digging Deeper

Not Quite Nodular

This biopsy came from a 70-year-old gentleman with acute renal failure. He had a known history of diabetes, hypertension, and…

By Nidia Messias, MD
Obesity-Related Glomerulopathy
Teaching Points

Membranous Glomerulopathy in Obesity-Related Glomerulopathy

The patient is a 57-year-old female, with a history of morbid obesity and persistent mild proteinuria (approximately 1 gm), who…