In patients with chronic kidney disease, toxins normally excreted by the kidney continue to circulate, leading to increased kidney damage. The gut microbiome likely plays a role in this damage and contributes to systemic inflammation. Supplementation with dietary fiber (resistant starch) may prevent this kidney damage. This study uses a mouse model of chronic kidney disease and showed that mice fed resistant starch had significantly less kidney fibrosis. A diet including resistant starch altered the gut microbiome, with changes detected in proteins involved in gut permeability and the inflammatory response. This dietary change may improve outcomes in patients living with chronic kidney disease.
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