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Unresolved etiologies, Throwback Thursday, Dr. Fred Silva, Arkana Laboratories

Unresolved Etiologies: When the Clinical Acumen Takes Place

Dr. Silva comments on several diagnostic dilemmas where the pathology pattern leads to a plethora of possibilities.

Fred Silva, MD renal pathologist at arkana laboratories
By Dr. Fred Silva
Anti-Brush Border Antibody Disease
Art of Medicine

Art of Medicine: Anti-Brush Border Antibody Disease

The above painting shows massive tubular basement membrane (electron dense on EM) deposits along proximal tubules with sparing of the…

Twitter Poll

Twitter Poll (August 7, 2019)

ANSWER: D, AIN The most common finding on kidney biopsies in patients with immune checkpoint inhibitors (ICPIs)induced AKI is acute…

By Vanessa Moreno, MD

Inflammatory Bowel Disease, IBD, renal disease, chronic kidney disease, renal biopsy, Arkana Laboratories
Disease Week

Disease Week: Renal Manifestations of Inflammatory Bowel Disease (IBD)

Monday Extraintestinal manifestations of inflammatory bowel disease are common and involve nearly every organ system. Renal and urinary involvement has…

Membranous glomerulopathy
Teaching Points

IgG4 Membranous

First identified in the pancreas as autoimmune pancreatitis, the IgG4-related disease is now known to affect many organs and body…

Interstitial Eosinophils
Teaching Points

Interstitial Eosinophils

Prominent interstitial eosinophils (see arrow) are most often associated with allergic-type acute interstitial nephritis (AIN). However, interstitial eosinophils are not…

Sjogrens Syndrome
Teaching Points


Sjgrens syndrome is an autoimmune disease involving primarily the lacrimal and salivary glands. However, up to 27% of patients will…

renal biopsy, arkana laboratories, renal tissue,granulomatous interstitial nephritis
Teaching Points

Granulomatous Interstitial Nephritis

The photomicrograph shows an interstitial granuloma from a case of granulomatous interstitial nephritis. The presence of granulomas within interstitial nephritis…

Chronic Active Tubulointerstitial Nephritis
Teaching Points

Chronic Active Tubulointerstitial Nephritis

Chronic tubulointerstitial nephritis in children may be secondary to a number of possible etiologies such as drug and other exogenous…

Megalocytic Interstitial Nephritis
Teaching Points

Megalocytic Interstitial Nephritis

This biopsy shows a chronic active interstitial nephritis with numerous interstitial foamy macrophages containing abundant PAS-positive cytoplasmic granules (Fig 1-3).…

Tubulointerstitial nephritis with uveitis
Teaching Points

Tubulointerstitial Nephritis with Uveitis

Tubulointerstitial nephritis with uveitis (TINU) was first described as a distinct entity by Dobrin, et al. in 1975. TINU primarily…

(CIN) Chronic Interstitial Nephritis
Teaching Points

Chronic Interstitial Nephritis

Chronic interstitial nephritis is a diagnosis made on renal biopsy when interstitial inflammation is present in a background of fibrosis…

positive adenovirus IHC stain
Diagnose This!

Diagnose This! (June 19, 2017 )

Whats your diagnosis in this renal transplant?   …

By L. Nich Cossey, MD
Eosinophil-Rich Inflammation in Diabetic Glomerulopathy
Teaching Points

Eosinophil-Rich Inflammation in Diabetic Glomerulopathy

These photomicrographs are from a patient with diabetic nephropathy as evidenced by the Kimmelstiel-Wilson nodules in the glomerulus present on…

IgG4-Positive Plasma Cells
Teaching Points


Renal parenchyma with florid interstitial fibrosis with thick bands of sclerosis expanding the interstitium and pushing the tubules apart on…