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Granulomatous Interstitial Nephritis

Chris Larsen, MD renal pathologist at arkana laboratories
By Chris Larsen, MD

Sep 07, 2017

renal biopsy, arkana laboratories, renal tissue,granulomatous interstitial nephritis

The photomicrograph shows an interstitial granuloma from a case of granulomatous interstitial nephritis. The presence of granulomas within interstitial nephritis frequently raises the differential diagnosis of unusual infections such as fungal and mycobacterial. However, a case series conducted within the United States showed that drug-induced reactions are the etiology of 45% of granulomatous interstitial nephritis cases followed by sarcoidosis in another 30%. The remaining 25% included 10% of cases that were idiopathic and 15% due to a variety of other etiologies such as systemic vasculitis, foreign body giant cell reaction, and infection.

Reference: Bijol V, et al. Int J Surg Pathol 14: 57-63, 2006


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