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September 7, 2017
Granulomatous Interstitial Nephritis

- Published: September 7, 2017
- By: Chris Larsen, MD and Arkana Author
- Tags: Acute kidney injury, Granulomatous interstitial nephritis, Interstitial nephritis
The photomicrograph shows an interstitial granuloma from a case of granulomatous interstitial nephritis. The presence of granulomas within interstitial nephritis frequently raises the differential diagnosis of unusual infections such as fungal and mycobacterial. However, a case series conducted within the United States showed that drug-induced reactions are the etiology of 45% of granulomatous interstitial nephritis cases followed by sarcoidosis in another 30%. The remaining 25% included 10% of cases that were idiopathic and 15% due to a variety of other etiologies such as systemic vasculitis, foreign body giant cell reaction, and infection.
Reference: Bijol V, et al. Int J Surg Pathol 14: 57-63, 2006