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Apolipoprotein A-IV Amyloidosis
Teaching Points

Apolipoprotein A-IV Amyloidosis

This renal biopsy from a 71-year-old female, who presented with progressively worsening renal failure, shows unremarkable glomeruli by light microscopy…

Teaching Points

Anti-Brush Border Antibody Disease IF

These photomicrographs show the classic immunofluorescence staining pattern for anti-LRP2 nephropathy, a disease that leads to severe renal tubular injury…

IgG4-Related Tubulointerstitial Nephritis
Teaching Points

IgG4-Related Tubulointerstitial Nephritis

IgG4-related disease is a systemic inflammatory and sclerosing disorder which may affect a wide range of different organs including the…


Calcium Phosphate Deposits
Teaching Points

Calcium Phosphate Deposits

Calcium phosphate deposits within the kidney may be seen in the setting of hypercalcemia/ hypercalciuria or hyperphosphatemia/ hyperphosphaturia. Regardless of…

Immunotactoid Glomerulopathy
L. Nich Cossey, MD
By L. Nich Cossey, MD
Malakoplakia
Diagnose This!

Diagnose This! (October 9, 2017)

What is your diagnosis?   …

L. Nich Cossey, MD
By L. Nich Cossey, MD

Monoclonal Gammopathy
Teaching Points

Monoclonal Gammopathy of Renal Significance

The renal biopsy shown here has an MPGN pattern of injury by light microscopy. Routine immunofluorescence on the fresh (unfixed)…

chronic transplant arteriopathy
Teaching Points

Chronic Transplant Arteriopathy

This image shows an arterial cross-section with features of chronic transplant arteriopathy (a.k.a. sclerosing transplant vasculopathy and chronic allograft vasculopathy).…

IgG4-Related Disease
L. Nich Cossey, MD
By L. Nich Cossey, MD

Sjogrens Syndrome
Teaching Points

Sjogrens

Sjgrens syndrome is an autoimmune disease involving primarily the lacrimal and salivary glands. However, up to 27% of patients will…

Fabry Disease
L. Nich Cossey, MD
By L. Nich Cossey, MD
Chronic Active Tubulointerstitial Nephritis
Teaching Points

Chronic Active Tubulointerstitial Nephritis

Chronic tubulointerstitial nephritis in children may be secondary to a number of possible etiologies such as drug and other exogenous…


Malakoplakia
Teaching Points

Malakoplakia

An adult patient in the mid-fifties with a deceased donor renal transplant for three years (primary disease hypertensive nephrosclerosis) presented…

Patrick D. Walker, MD renal pathologist at arkana laboratories
By Patrick D. Walker, MD
Renal hemosiderosis
Teaching Points

Hemosiderin

Renal hemosiderosis is a rare etiology of kidney injury that occurs secondary to diseases with chronic intravascular hemolysis. The most…

Megalocytic Interstitial Nephritis
Teaching Points

Megalocytic Interstitial Nephritis

This biopsy shows a chronic active interstitial nephritis with numerous interstitial foamy macrophages containing abundant PAS-positive cytoplasmic granules (Fig 1-3).…