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Chris Larsen, MD renal pathologist at arkana laboratories
By Chris Larsen, MD

Aug 17, 2017

Renal hemosiderosis

Renal hemosiderosis is a rare etiology of kidney injury that occurs secondary to diseases with chronic intravascular hemolysis. The most common associated conditions include paroxysmal nocturnal hemoglobinuria, sickle cell anemia, and the presence of a mechanical heart valve. It results from free hemoglobin being filtered by the glomeruli and reabsorbed by the proximal tubules. H&E and PAS sections show proximal tubules with cytoplasmic golden yellow to brown, granular pigment. These granules stain blue on a Prussian blue iron stain.

PAS stain showing Renal hemosiderosis

Prussian blue stain of renal cortex


Quick note: This post is to be used for informational purposes only and does not constitute medical or health advice. Each person should consult their own doctor with respect to matters referenced. Arkana Laboratories assumes no liability for actions taken in reliance upon the information contained herein.